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research A molecular wound response program associated with regeneration initiation in planarians

212 citations , May 2012 in “Genes & Development”

This study identified a set of wound-induced genes in planarians that play a role in regeneration initiation, with some genes specifically activating within regenerative cells called neoblasts.

research Spatial transcriptomics reveals asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear

1 citations , August 2023 in “Genome research”

This study found that in spiny mice, the proximal side of ear wounds is crucial for regeneration, a process possibly linked to unique injury-induced immune responses compared to nonregenerative rodents.

research Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

328 citations , November 2020 in “Nature Materials”

This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.

research The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease

November 2025 in “Biocell”

This article explores how the integrated stress response and senescence-associated secretory phenotype influence stem cell fate decisions, highlighting their dual roles in both protecting and disrupting stem cell integrity.

research Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

527 citations , December 2011 in “Proceedings of the National Academy of Sciences”

This study found that dextran-based hydrogels promoted significant neovascularization and skin regeneration in mouse models of third-degree burns, without the need for additional growth factors or cells.

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Community Join

5 / 314 results

community Has anyone here actually tried Shiseido’s S-DSC hair regenerative treatment in Japan?

14 upvotes 4 months ago

Shiseido's S-DSC hair regenerative treatment in Japan focuses on improving existing hair by thickening miniaturized follicles, not creating new ones. There is limited patient feedback and long-term data available.

community Pelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Presented at the American Academy of Dermatology (AAD) Annual Meeting 2026

122 upvotes 6 months ago

PP405 shows promise in regenerating hair by activating dormant follicles. Other treatments like VDPHL01 and Breezula are also advancing, providing new hope for hair loss solutions.

community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

53 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

community People are misunderstanding PP405. 31% response at 8 weeks is better than you think

181 upvotes 1 year ago

PP405 shows promise as a hair loss treatment, with 31% experiencing increased hair density in a short trial. It may complement treatments like finasteride and minoxidil, but long-term effectiveness and safety need confirmation.

community Am i a hyper responsive ? Why i see results on areas i don’t put products in?

490 upvotes 7 months ago

The user saw significant hair regrowth using topical minoxidil and finasteride, even on areas not directly treated. They used local Algerian products with 5% minoxidil and 0.1% finasteride and reported no side effects.

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Learn

9 / 801 results

learn Beta Polypeptide

learn Thymosin Beta 4

What is Thymosin Beta 4, and why is it being researched in relation to hair follicle function and regeneration? Thymosin Beta 4 is a peptide being researched for its potential to enhance hair follicle regeneration.

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

learn Epidermal Growth Factor

learn Redensyl

Does Redensyl regenerate follicles or only strengthen existing hair? Redensyl primarily strengthens existing hair rather than regenerating new follicles.

learn Exosomes

What are exosomes and how do they help regenerate hair in cases of severe hair loss? Exosomes are tiny vesicles that promote hair regeneration by signaling hair follicle cells.

learn Verteporfin

What is Verteporfin, and why is it being studied for hair follicle regeneration? Verteporfin is being studied for hair follicle regeneration due to its ability to inhibit YAP, promoting tissue healing.

learn Rosemary

Rosemary helps circulation, but does that actually regenerate hair? Rosemary may improve circulation but does not directly regenerate hair.

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Clinics

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