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Glossary Randomized Controlled Trials

scientific studies comparing treatments by randomly assigning participants

Randomized Controlled Trials (RCTs) are scientific studies designed to test the effectiveness of medical treatments or interventions by randomly assigning participants to either a treatment group or a control group. This randomization helps eliminate bias, ensuring that any differences observed between the groups can be attributed to the treatment itself rather than other factors. RCTs are considered the gold standard in clinical research for establishing causality and assessing the efficacy and safety of new therapies.

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Research

5 / 1000+ results

Randomized Control Trial to Study the Efficacy and Safety of Platelet-Rich Plasma as Intraoperative Holding Solution in Hair Restoration Surgery: A Pilot Study

research Randomized control trial to study the efficacy and safety of platelet-rich plasma as intraoperative holding solution in hair restoration surgery: A pilot study

July 2021 in “Medical journal, Armed Forces India”

This study reported that using platelet-rich plasma as an intraoperative holding solution significantly improved hair density and follicular growth in hair restoration surgery for androgenetic alopecia.

A Randomized Control Trial Comparing the Efficacy of Platelet-Rich Plasma and 5% Topical Minoxidil for the Treatment of Androgenetic Alopecia

research A Randomized Control Trial Comparing the Efficacy of Platelet-Rich Plasma and 5% Topical Minoxidil for the Treatment of Androgenetic Alopecia.

September 2023 in “PubMed”

In this study, researchers found that platelet-rich plasma therapy demonstrated significantly higher efficacy than topical minoxidil for treating androgenetic alopecia in a Pakistani population, with a 91.7% negative hair pull rate compared to 69.4% for minoxidil after 12 weeks.

research Randomized Control Clinical Trial to assess the combine effect of Bhringaraja Taila Shiroabhyanga and Yastimadhuka Taila Nasya in Khalitya of Females

August 2025 in “International Journal of Ayurveda360”

In this randomized controlled trial, the combination of Bhringaraja Taila Shiroabhyanga and Yastimadhuka Taila Nasya was found to significantly improve hair density, reduce hair fall, and decrease scalp visibility in females with Khalitya compared to Nasya alone, with no reported adverse effects.

Comparison of the Efficacy of Topical Methotrexate 1% Gel Versus Topical Betamethasone Dipropionate 0.05% Lotion in the Treatment of Localized Scalp Alopecia Areata in a Tertiary Care Institute of Central India: A Randomized Control Trial

research Comparison of the Efficacy of Topical Methotrexate 1% gel Versus Topical Betamethasone Dipropionate 0.05% Lotion in the Treatment of Localized Scalp Alopecia Areata in a Tertiary Care Institute of Central India: A Randomized Control Trial

August 2025 in “Indian Dermatology Online Journal”

In this study, both methotrexate gel and betamethasone lotion were found to be effective and safe treatments for localized alopecia areata, with similar overall response rates. However, methotrexate gel had a higher incidence of local side effects, such as irritant dermatitis and itching.

Phototherapy with Topical Minoxidil in Vitiligo: A Randomized Controlled Trial

research Phototherapy with Topical Minoxidil in Vitiligo: A Randomized Control Trial

August 2025 in “Indian Dermatology Online Journal”

This study found that combining topical minoxidil with phototherapy significantly improved pigmentation and reduced vitiligo severity compared to placebo, as measured by VASI scores over 12 weeks, though the sample size was small and follow-up short.

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community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

308 upvotes 1 year ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community Does creatine cause hair loss? A 12-week randomized controlled trial - PubMed

24 upvotes 1 year ago

Creatine does not directly cause hair loss, but it may increase DHT levels, which can affect hair. Some users report hair shedding with creatine, while others experience no hair loss.

community Korean Laser Helmet has a 44% increase in hair growth vs 0% growth in placebo in a double-blinded randomized controlled clinical trial.

3037 upvotes 11 months ago

A Korean laser helmet increases hair growth by 44% compared to a placebo. Users discuss its cost-effectiveness, clinical support, and compare it to treatments like finasteride and minoxidil, focusing on wavelength and energy density.

community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 30 upvotes 5 months ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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learn Epidermal Growth Factor

learn Thymosin Beta 4

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