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research Comparison of the formulation and allergenic potential of “clean” and traditional shampoos

October 2022 in “Journal of the American Academy of Dermatology”

This study found that "clean" shampoos are less likely to contain allergenic preservatives compared to traditional shampoos, but both types use fragrance equally, which can be irritating or allergenic.

research Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series

23 citations , January 2016 in “Contact Dermatitis”

This study found that a small number of patients with essential oil allergies could be missed if only standard fragrance tests are used, suggesting the need for specific testing and careful product inspection.

research Controversy: Synthetic hairs and their role in hair restoration?

10 citations , January 2010 in “International Journal of Trichology”

This article reviews the use of artificial hair fibers, discussing their controversial history and the FDA ban, and reports no new research findings.

research Pediatric Hair Cosmetics: Physiology, Safety and Product Considerations

March 2026 in “Skin Appendage Disorders”

This narrative review highlights the distinct needs of pediatric hair care, emphasizing gentler formulations due to differences in children's hair physiology, structure, and barrier function, and calls for targeted regulations and research due to limited safety evidence.

research Analysis of Common Treatment Drugs and Allergen Sensitization in Hair Loss Patients

February 2025 in “Journal of Cosmetic Dermatology”

This study examined the sensitization potential of common hair care products and found that certain ingredients, like cobalt chloride and nickel sulfate, frequently cause allergic reactions in individuals with hair diseases, providing essential insights for personalized treatment strategies.

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Community Join

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community Can the ingredients in a sebum-regulating shampoo induce hair diameter reduction?

2 upvotes 1 year ago

A user experienced hair thinning and scalp issues after using a sebum-regulating shampoo and perm treatments. They are advised to consider potential allergies, try a simple shampoo, and research treatments like finasteride for possible male pattern baldness.

community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

89 upvotes 10 months ago

The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.

community Im still very very afraid of a possible ban of Finasteride and dutasteride in the EU

in Finasteride/Dutasteride 38 upvotes 1 year ago

There is concern about a potential ban on finasteride and dutasteride in the EU, with users discussing the impact on hair loss treatment. Some suggest alternative treatments or express skepticism about the likelihood of a ban.

community DIY Cetirizin topical 1% with micro needling

2 upvotes 8 months ago

The conversation is about using a DIY topical Cetirizine 1% solution with microneedling for hair loss treatment. Concerns were raised about potential side effects and the effectiveness of Cetirizine for this purpose.

community Creatine made all my high DHT symptoms return

82 upvotes 1 year ago

Creatine may increase DHT levels, potentially causing symptoms like acne, oily hair, and hair shedding. Users report mixed experiences, with some avoiding creatine due to hair loss concerns and others seeing no impact.

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Learn

7 / 33 results

learn Bimatoprost

Prostaglandin eye drop used for glaucoma and eyelash growth

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn SCUBE3

What is SCUBE3 and why is it being studied as a potential breakthrough for hair regrowth? SCUBE3 is a signaling protein that made resting hair follicles start growing in mouse experiments in a 2022 study. It has not been tested in people and is not an approved treatment.

learn Setipiprant

How does Setipiprant work on the scalp to potentially promote hair regrowth? Setipiprant blocks the DP2 (CRTH2) receptor that prostaglandin D₂ acts through, and PGD₂ is reported to be elevated in balding scalp — but the one published placebo-controlled trial in men (DuBois 2021, n=169) found no significant hair regrowth. It is an experimental compound, not an approved hair-loss medicine.

learn Valproic acid

Why is valproic acid not considered a standard cosmetic ingredient despite its potential effects on hair growth? Valproic acid is a prescription anticonvulsant with a boxed warning for liver failure, pancreatitis and harm to an unborn baby, so it is regulated as a drug, not a cosmetic. Its hair-growth evidence is mostly cell and mouse work plus one small human trial, and oral valproate itself causes hair loss in some patients.

learn Rapamycin

What is rapamycin, and how is it being studied as a potential treatment for hair loss? Rapamycin is being studied for hair loss due to its effects on the mTOR pathway.

learn TDM-105795

What is TDM-105795, and why is it being studied as a potential product for hair loss and hair growth support? TDM-105795 is an experimental topical drug that has been tested only in men with androgenetic alopecia, in two Phase 1 studies and one 16-week Phase 2 trial of 71 men. It is not approved, and no peer-reviewed trial results have been published.

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