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    Glossary Phosphodiesterase Inhibitors

    block enzymes that break down cyclic nucleotides

    Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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    Research 10 of 563

    1. PD59-09 PHOSPHODIESTERASE INHIBITORS COULD REVERSE THE PROLIFERATION OF BPH EPITHELIAL CELLS INDUCED BY CD8+ T CELLS IN LOW ANDROGEN CONDITION The Journal of Urology · 2018
    2. Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions Springer eBooks · 2018
    3. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    4. The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms Journal of Dermatological Science · 2018 · 21 citations
    5. Efficacy of the phosphodiesterase-4 inhibitor, apremilast, in a patient with severe alopecia areata European Journal of Dermatology · 2019 · 10 citations
    6. The effects of phosphodiesterase 3 (PDE3) inhibitor on hair follicle cell viability and hair growth Seoul National University Open Repository (Seoul National University) · 2020 · 1 citations
    7. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    8. The use of phosphodiesterase inhibitors for the treatment of alopecia Journal of Dermatological Treatment · 2019 · 3 citations
    9. Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors? Journal of The European Academy of Dermatology and Venereology · 2020 · 1 citations
    10. 467 Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss Journal of Investigative Dermatology · 2021
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