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    Did you mean Phosphodiesterase Inhibitors?
    Glossary Phosphodiesterase Inhibitors

    block enzymes that break down cyclic nucleotides

    Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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    Research 30 of 563

    1. PD59-09 PHOSPHODIESTERASE INHIBITORS COULD REVERSE THE PROLIFERATION OF BPH EPITHELIAL CELLS INDUCED BY CD8+ T CELLS IN LOW ANDROGEN CONDITION The Journal of Urology · 2018
    2. Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions Springer eBooks · 2018
    3. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    4. The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms Journal of Dermatological Science · 2018 · 21 citations
    5. Efficacy of the phosphodiesterase-4 inhibitor, apremilast, in a patient with severe alopecia areata European Journal of Dermatology · 2019 · 10 citations
    6. The effects of phosphodiesterase 3 (PDE3) inhibitor on hair follicle cell viability and hair growth Seoul National University Open Repository (Seoul National University) · 2020 · 1 citations
    7. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    8. The use of phosphodiesterase inhibitors for the treatment of alopecia Journal of Dermatological Treatment · 2019 · 3 citations
    9. Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors? Journal of The European Academy of Dermatology and Venereology · 2020 · 1 citations
    10. 467 Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss Journal of Investigative Dermatology · 2021
    11. Phosphodiesterase inhibitors used in androgenic alopecia as a possible risk factor for testicular tumor Medicina Clínica (english Edition) · 2023
    12. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) Figshare · 2026
    13. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) Figshare · 2026
    14. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) The Aging Male · 2026
    15. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    16. FDA approves label addition for PDE-5 inhibitor Urology Times eNews · 2013
    17. 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration Journal of Investigative Dermatology · 2024
    18. Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015 · 15 citations
    19. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    20. Investigation, treatment and monitoring of late‐onset hypogonadism in males: ISA, ISSAM, and EAU recommendations Andrology · 2005 · 280 citations
    21. Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia Frontiers in Pharmacology · 2020 · 35 citations
    22. Risks and side effects in the medical management of benign prostatic hyperplasia Prostate International · 2023 · 26 citations
    23. Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review Curēus · 2023 · 1 citations
    24. Wider clinical applications of fumaric acid esters: A useful option in psoriasis patients with multiple sclerosis Journal of The American Academy of Dermatology · 2015 · 1 citations
    25. Medical management of benign prostatic hyperplasia Cleveland Clinic journal of medicine · 2024
    26. Platelet-Rich Plasma for Urologic Conditions: An Early Call for Composition Reporting The Journal of Urology · 2023
    27. Most recent findings of curative drugs for lower urinary tract symptoms in clinical practice Nihon Yakuri Gakkai nenkai yoshishu · 2019
    28. Treatment of actinic cheilitis with ingenol mebutate gel: Experience in four patients Journal of The American Academy of Dermatology · 2015
    29. Study of QuantiFERON’S conversion/reversal phenomena in patients with psoriasis during biological treatment Journal of The American Academy of Dermatology · 2015
    30. 8 Finasteride-Associated Suicide and Depression in Men Treated for Hypogonadism and Impotence The Journal of Sexual Medicine · 2022