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GlossaryPeroxisome Proliferator-Activated Receptor Gamma

nuclear receptor protein regulating genes for fat storage and glucose metabolism

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a type of nuclear receptor protein that regulates the expression of specific genes involved in fat storage, glucose metabolism, and inflammation. It plays a crucial role in the development of adipose tissue and is a target for drugs used to treat conditions like type 2 diabetes and metabolic syndrome.

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Peroxisome Proliferator Activated Receptors Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study

research Peroxisome Proliferator Activated Receptors Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study

July 2022 in “Research Square (Research Square)”

This study involving 93 Egyptian female patients with Frontal Fibrosing Alopecia (FFA) and 157 healthy controls found that FFA patients had significantly lower serum levels of Peroxisome Proliferator Activated Receptors Gamma (PPARγ) and a higher prevalence of the PPARG (Pro12Ala) gene polymorphism. These genetic variations were linked to reduced PPARγ levels and increased FFA severity, suggesting that PPARγ could be a crucial biomarker for FFA. Although the study indicates the potential of PPARγ agonists in treating FFA, it could not evaluate their therapeutic efficacy due to patient compliance issues.

research Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics?

60 citations, May 2015 in “Archives of dermatological research”

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

research How to Diagnose a Lipodystrophy Syndrome

53 citations, June 2012 in “Annales d'Endocrinologie”

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

research The Aetiopathogenesis of Acne Vulgaris: What's New?

14 citations, April 2014 in “International Journal of Cosmetic Science”

Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations, January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.