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research Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

31 citations , February 2007 in “Molecular Carcinogenesis”

This study found that transgenic mice overexpressing human ATF3 showed hyperplastic and dysplastic changes in epithelial tissues, with a high incidence of oral cancer, suggesting potential oncogenic properties of ATF3.

research PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells

2 citations , July 2024 in “Bioengineering”

This study found that platelet-rich fibrin lysates modulate chemokine expression, reducing inflammation in oral squamous carcinoma cells, but increasing expression in primary oral epithelial cells.

research Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway

9 citations , September 2024 in “Scientific Reports”

This study found that cardamonin may inhibit OSCC cell migration, proliferation, and invasion by affecting the PI3K/AKT pathway, suggesting its potential as a treatment.

research Expression of Keratin 75 (K6hf) in Oral Squamous Cell Carcinoma

2 citations , January 2011 in “Dental Medicine Research”

This study suggests that Keratin 6hf may be a potential marker of oral squamous cell carcinoma and could play a role in its progression, though further research is needed to understand its function.

research Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata

23 citations , October 2024 in “British Journal of Dermatology”

In this study, ritlecitinib showed sustained effectiveness and a favorable safety profile in treating alopecia areata in patients aged 12 and older over 24 months, with improvements observed in hair and eyebrow regrowth and patient satisfaction.

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community On dutasteride, looking for alternatives to minoxidil

in Treatment 8 upvotes 2 months ago

The user stopped using topical minoxidil due to side effects and is now on dutasteride, seeking alternatives to minoxidil. Suggestions include oral minoxidil, foam minoxidil, KOSHINÉ, PRFM, and ketoconazole shampoo for dandruff.

community Am I wasting my time with this? Need advice

in Is this regrowth? 37 upvotes 1 year ago

The user has been using a combination of finasteride and minoxidil for 5 months and is considering adding dutasteride due to slow progress. They plan to alternate between oral finasteride and dutasteride to save costs and are advised to continue the treatment for more time, possibly adding tretinoin, while considering a hair transplant if results remain unsatisfactory.

community Update: going nuclear! (Switch to dut)

in Update 13 upvotes 5 months ago

The user had a hair transplant in March 2025 and has been using finasteride since 2023, which halted hair loss but didn't fully restore density. They plan to use dutasteride twice weekly, finasteride five times a week, and saw palmetto to improve hair thickness.

community Costco sale on minoxidil starts today!

850 upvotes 1 year ago

Minoxidil is on sale at Costco, but it poses a significant risk to pets, especially cats. Users discuss the pros and cons of foam versus liquid minoxidil, with some preferring liquid for better results despite its greasiness and dandruff issues.

community My hair stopped falling out after I quit smoking

in Update 60 upvotes 1 year ago

Quitting smoking led to reduced hair loss for the original poster, who also used finasteride and topical minoxidil. Other users shared mixed experiences with smoking and hair loss, with some noticing improvements after quitting and others seeing no change.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Metformin

Is metformin used topically for hair loss, or only as an oral tablet? Approved metformin products are oral tablets only; there is no approved topical metformin for hair loss. Published human reports of topical use are a handful of uncontrolled, pharmacy-compounded case reports in scarring alopecia, and the most-cited clinical series actually used the oral drug.

learn Sulforaphane

Is sulforaphane used in oral supplements or topical hair treatments? Sulforaphane is primarily used in oral supplements, not topical hair treatments.

learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

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