PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells

The study examines the impact of platelet-rich fibrin (PRF) lysates on chemokine expression in oral squamous carcinoma cell lines (HSC2 and TR146) and primary oral epithelial cells. PRF lysates significantly suppress chemokine expression induced by inflammatory cytokines IL1β and TNFα in carcinoma cells, suggesting anti-inflammatory potential. In contrast, PRF lysates increase chemokine expression in healthy epithelial cells, indicating a role in enhancing innate immunity. These findings suggest a dual role for PRF in modulating chemokine expression, which could influence therapeutic strategies for oral health and cancer treatment. However, the study advises caution in applying these in vitro results clinically and calls for further research to understand the differential responses of malignant and healthy cells to PRF.