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GlossaryOncogenic Mutations

changes in DNA that can lead to cancer

Oncogenic mutations, also known as cancer-causing mutations, are changes in the DNA that can transform a normal cell into a cancerous one. These mutations often occur in genes that regulate cell growth, division, and death, such as oncogenes and tumor suppressor genes, leading to uncontrolled cell proliferation and tumor formation.

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Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

research Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

July 2022 in “Journal of Investigative Dermatology”

A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.

Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation

research Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.

research Acute Sensitivity of the Oral Mucosa to Oncogenic K-ras

12 citations, March 2011 in “Journal of pathology”

Oncogenic K-ras causes rapid cancerous changes in the mouth's lining.

research Tracing the Cellular Origin of Cancer

232 citations, January 2013 in “Nature Cell Biology”

Understanding where cancer cells come from helps create better prevention and treatment methods.

research Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

403 citations, December 2018 in “Cell stem cell”

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

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