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    Did you mean Oncogenic Mutations?
    Glossary Oncogenic Mutations

    changes in DNA that can lead to cancer

    Oncogenic mutations, also known as cancer-causing mutations, are changes in the DNA that can transform a normal cell into a cancerous one. These mutations often occur in genes that regulate cell growth, division, and death, such as oncogenes and tumor suppressor genes, leading to uncontrolled cell proliferation and tumor formation.

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    1. LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation Journal of Investigative Dermatology · 2022
    2. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    3. Acute sensitivity of the oral mucosa to oncogenic <i>K‐ras</i> Journal of pathology · 2011 · 12 citations
    4. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    5. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    6. Clonal analysis of stem cells in differentiation and disease Current Opinion in Cell Biology · 2016 · 11 citations
    7. Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling Journal of Investigative Dermatology · 2010 · 29 citations
    8. Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle Science · 2026
    9. Somatic Mutations in Normal Tissues: New Perspectives on Early Carcinogenesis Annual Review of Cancer Biology · 2023 · 13 citations
    10. Drug Repurposing against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study International Journal of Molecular Sciences · 2022
    11. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations
    12. PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands Journal of Experimental & Clinical Cancer Research · 2025 · 7 citations
    13. Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes All Life · 2024 · 3 citations
    14. Roles of tumor suppressors in regulating tumor-associated inflammation Cell Death & Differentiation · 2014 · 44 citations
    15. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors Scientific Reports · 2021 · 4 citations
    16. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update Journal of Dermatological Science · 2012 · 52 citations
    17. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    18. Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease Cell Reports · 2022 · 14 citations
    19. Molecular pathology of skin adnexal tumours Histopathology · 2021 · 16 citations
    20. Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis PLOS ONE · 2013 · 8 citations
    21. Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective Trends in Cell Biology · 2023 · 45 citations
    22. In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis Pharmaceuticals · 2023
    23. A cross-sectional study of clinical, dermoscopic, histopathological, and molecular patterns of scalp melanoma in patients with or without androgenetic alopecia Scientific Reports · 2022
    24. Tracing the cellular origin of cancer Nature Cell Biology · 2013 · 232 citations
    25. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    26. Cellular heterogeneity and microenvironmental control of skin cancer Journal of Internal Medicine · 2020 · 16 citations
    27. Proteolysis‐targeting chimeras in cancer therapy: Targeted protein degradation for next‐generation treatment Cancer · 2025 · 3 citations
    28. Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models iScience · 2019 · 5 citations
    29. The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs) Proteomes · 2023 · 4 citations
    30. Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells Medical Sciences · 2017 · 37 citations