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    Glossary oncogene

    gene that can cause cancer when mutated or overexpressed

    An oncogene is a type of gene that, when mutated or expressed at high levels, can transform a normal cell into a cancerous one. In simpler terms, it's like a switch that, when turned on incorrectly, can lead to uncontrolled cell growth and potentially cancer. For professionals, oncogenes are often derived from proto-oncogenes, which are normal genes involved in cell growth and division, but become harmful when altered.

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    1. Acute sensitivity of the oral mucosa to oncogenic <i>K‐ras</i> Journal of pathology · 2011 · 12 citations
    2. Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis<i>in vivo</i> bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    3. Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma British Journal of Dermatology · 2017
    4. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    5. LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation Journal of Investigative Dermatology · 2022
    6. Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice Oncogene · 1999 · 150 citations
    7. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    8. Ontogenetic Transition in Fetal Wound Transforming Growth Factor-β Regulation Correlates with Collagen Organization American Journal of Pathology · 2003 · 109 citations
    9. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease Nature Communications · 2019 · 67 citations
    10. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation Nature Cell Biology · 2024 · 19 citations
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