learn Metformin
diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties
Search
forLearn
1 / 1 resultsResearch
5 / 1000+ resultsresearch A Comprehensive Investigation Into the Molecular Mechanism Responsible for Selective Androgen Receptor Modulator Tissue-Selectivity
The study investigated the molecular mechanism behind the tissue-selectivity of selective androgen receptor modulators (SARMs) by analyzing the conformation of the androgen receptor (AR) using various techniques. Despite initial challenges with biotinylation, further analysis revealed ligand-specific cofactors, notably identifying nuclear receptor corepressor (NCoR) exclusively in SARM-treated samples. This was confirmed by observing a higher degree of AR-SARM/NCoR association compared to AR-DHT/NCoR. Additionally, differences in cytoplasmic-nuclear transport and nuclear foci formation between AR-SARM and AR-DHT were noted. The findings suggested that AR-SARM complexes have distinct structural and functional properties, providing insights into the SARM tissue-selective mechanism and potential research directions.
research Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms
Beta-HPV and MCPyV are linked to certain skin cancers, with ongoing research and vaccine development.
research Cellular Senescence and Aging in Myotonic Dystrophy
Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.
research Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching Is an Integrated Measure of Receptor Function
Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.
research Molecular Genetic and Endocrine Mechanisms of Hair Growth
Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.
Community Join
5 / 521 resultscommunity Nuclear stack not working still
A 20-year-old has been using topical minoxidil since 2021, oral finasteride since 2023, oral minoxidil for 6 months, and dutasteride for 2 months to combat hair loss but is still experiencing temple thinning. Suggestions include continuing medication, considering a future hair transplant, and taking monthly progress pictures.
community Nuclear topical fin formulation?
The conversation discusses a hair loss treatment involving oral minoxidil, topical finasteride, and a custom topical formulation with minoxidil, cetirizine, finasteride, progesterone, and hydrocortisone. The user seeks advice on the effectiveness of these ingredients for diffuse thinning.
community Nuclear stack: 2.5mg dutasteride vs 0.5mg dutasteride + topical finasteride/dutasteride/spironolactone for male pattern baldness
The conversation discusses using 2.5mg dutasteride, 0.5mg dutasteride with topical treatments, and other combinations like oral minoxidil, RU58841, and microneedling for male pattern baldness. Users share experiences and suggest various treatment regimens, emphasizing the effectiveness of dutasteride and minoxidil.
community Nuclear Stack Ineffective: Oral DUT/FIN/MIN/RU - NAFLD?
The user experienced severe hair shedding despite using oral finasteride, minoxidil, dutasteride, and RU58841, and was diagnosed with Non-Alcoholic Fatty Liver Disease (NAFLD). They are considering switching to topical treatments due to the ineffectiveness of their current regimen.
community ultimate nuclear stack? need more suggestions bruhh
The conversation discusses an extensive hair loss treatment regimen including dutasteride, GT20029, RU58841, pyrilutamide, minoxidil, microneedling, ketoconazole shampoo, and experimental compounds. The user humorously describes their approach as a comprehensive strategy to combat hair loss while maintaining hair growth.