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Research

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research Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)

289 citations , May 2003 in “Journal of Investigative Dermatology”

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

research Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions

37 citations , February 2007 in “Experimental Dermatology”

This study found that PDCD4 protein expression is reduced in various skin cancers compared to normal skin, suggesting its potential role in preventing or treating certain skin cancers.

research 054 Deep Analysis of CD4+ Trm Cells in Normal and Atopic Dermatitis Human Skin

November 2025 in “Journal of Investigative Dermatology”

Certain immune cells in atopic dermatitis skin could be targeted for treatment.

research The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

110 citations , August 2011 in “Journal of Visualized Experiments”

This research highlights the use of 3D human skin model reconstructs as a promising method to study human skin biology, showing that these models replicate natural melanocyte and melanoma behaviors accurately.

research The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

39 citations , August 2011 in “Journal of Visualized Experiments”

This review discusses the development and findings of 3D human skin models for studying melanocyte homeostasis and melanoma progression but reports no new clinical results.

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Community Join

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community Hair and normal skin created from human pluripotent stem cells for the first time

86 upvotes 6 years ago

Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.

community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 11 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

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Learn

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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Vascular Endothelial Growth Factor

learn Folic acid

Is there a difference between taking folic acid supplements and using folic acid in topical hair products? Oral folic acid uses the body's normal absorption route and can correct a measured deficiency, but no published trial shows it treats hair loss; topical folic acid has no human evidence for hair growth and struggles to cross the skin barrier at all.

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