17 citations
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January 2013 in “Journal of Cutaneous Pathology” The study introduced the concept of the onychodermis, a specialized mesenchymal substructure unique to the nail organ, characterized by its expression of CD10. Through immunohistochemical analysis, the researchers compared adult and fetal hair follicles with fetal nail organs, focusing on the expression of CD10, CD34, and nestin. They found that the CD10-positive/CD34-negative onychodermis was prominent by the end of the second trimester, with no corresponding structure in hair follicles. The onychodermis was suggested to play a role in anchoring the nail bed and possibly in inducing hard keratins, contributing to nail plate formation.
10 citations
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October 2016 in “Experimental Dermatology” Nail stem cells and Wnt signaling are important for fingertip regeneration but not sufficient for regenerating more complex limb structures.
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The HoxC gene cluster and its enhancers are essential for developing hair and nails in mammals.
14 citations
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February 2014 in “Experimental Cell Research” The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.
21 citations
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January 2005 in “Skinmed” Hair and nails are similar keratin structures with different shapes and growth, affected by the same diseases and environmental factors.