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research Finasteride Inhibits Human Prostate Cancer Cell Invasion through MMP2 and MMP9 Downregulation

63 citations , December 2013 in “PLoS ONE”

This study suggests that finasteride may reduce the aggressiveness and invasion of prostate tumors, with effects potentially differing based on the androgen responsiveness of the patient's prostate cells.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

This study suggests that in hidradenitis suppurativa, MMP-induced matrix alterations may contribute to inflammation by releasing active peptides and inflammatory factors in the extracellular matrix.

research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

This study found that Gelatinase A activity is linked to the absence of type VII collagen during human fetal skin development, indicating its role in remodeling the basement membrane zone.

research Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth

27 citations , June 2001 in “International Journal of Dermatology”

This study found that cytokine and EGF stimulation leads to increased MMP-9 production in hair follicles, a process involved in hair follicle involution associated with alopecia.

research Molecular modeling of hair keratin/peptide complex: Using MM‐PBSA calculations to describe experimental binding results

14 citations , January 2012 in “Proteins”

This study's molecular dynamics simulations suggest that electrostatic interactions mainly stabilize peptide binding to human hair keratin, with the protein's dielectric constant significantly affecting free energy calculations.

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community Microneedling frequency at 1.5 mm for hair growth

in Microneedling 1 upvotes 1 year ago

Microneedling at 1.5 mm should be done every 4 to 6 weeks, not weekly, to prevent scalp trauma and improve hair growth. The user is also using 0.5 mg dutasteride daily, 5 mg minoxidil daily, and started RU58841 two months ago.

community "When comparing 5% minoxidil with 0.60 mm or 1.20 mm needle lengths, Faghihi et al. found that 0.60 mm needle lengths led to significant hair count and diameter increases versus 5% minoxidil, whereas 1.20 mm needle lengths only saw hair count increases versus 5% minoxidil"

in Research/Science 60 upvotes 2 years ago

Microneedling with 0.6 mm needles combined with 5% minoxidil is more effective for hair count and thickness than minoxidil alone or with 1.2 mm needles. Biweekly microneedling at 0.6 mm depth is recommended for better results in treating androgenetic alopecia.

community Is microneedling with 0.75 mm weekly too aggressive?

5 upvotes 1 month ago

Microneedling with a 0.75 mm depth weekly may be too aggressive for scalp recovery, with some users suggesting longer recovery times. Opinions vary on its effectiveness for hair loss, with some users combining it with minoxidil and others questioning its efficacy and safety.

community 8 months minoxidil + dermaroller 0.5 mm (M50)

118 upvotes 1 month ago

The conversation is about using minoxidil and a dermaroller for hair loss treatment, with progress seen after 8 months. The user applies topical minoxidil twice daily and uses a dermaroller once a week, avoiding minoxidil 12 hours before and after rolling.

community 5 months on dermaroller 0.5 mm + min5%, 3 months on fin. M21

in Progress Pictures 70 upvotes 1 year ago

A 21-year-old has been using a 0.5 mm dermaroller weekly with 5% Minoxidil for five months and Finasteride for three months to address hair loss. The conversation includes questions about the frequency of dermarolling.

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