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Did you mean Microphthalmia-associated transcription factor?

Glossary Microphthalmia-associated transcription factor

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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Research

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research Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.

21 citations , February 2006 in “Clinical Cancer Research”

This commentary discusses how microphthalmic-associated transcription factor levels in circulating tumor cells correlate with melanoma progression and suggests the factor may be up-regulated in vivo, but it reports no new clinical results.

research The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor

4 citations , February 2023 in “International Journal of Stem Cells”

The FTO gene hinders stem cells in hair follicles from becoming pigment cells.

research Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor

33 citations , January 2015 in “Journal of Ginseng Research”

This study found that ginsenoside Rg3 significantly inhibited melanogenesis in human melanocytes and B16F10 cells by activating the ERK pathway, suggesting potential as a skin-whitening agent.

research The Peripheral Clock Regulates Human Pigmentation

81 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that silencing clock genes BMAL1 or PER1 in human hair follicles increased melanin content and melanocyte activity, suggesting these genes influence pigmentation.

research Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3

7 citations , August 2013 in “Experimental and Therapeutic Medicine”

In this study, the researchers optimized a method for culturing melanocyte precursors from hair follicles and found that 1,25-dihydroxyvitamin D3 significantly promotes their differentiation and melanin synthesis.

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community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

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