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Glossary MicroRNAs

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating gene expression by binding to messenger RNAs (mRNAs) and inhibiting their translation or promoting their degradation. In the context of hair loss and hair biology, miRNAs are involved in various processes such as hair follicle development, cycling, and the response to stressors that can lead to conditions like androgenetic alopecia. Key distinguishing characteristics of miRNAs include their ability to modulate multiple target genes simultaneously, which can influence cellular pathways related to hair growth and loss. Understanding the role of miRNAs in hair biology may offer insights into potential therapeutic targets for hair loss treatments.

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research MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives

June 2026 in “Frontiers in Cell and Developmental Biology”

This review outlines recent advancements in understanding how micro-RNAs (miRNAs) influence hair regeneration, highlighting their role in stimulating hair growth and potential therapeutic approaches, while also addressing the challenges of clinical translation due to miRNAs' complex roles and delivery issues.

research MicroRNA control of signal transduction

1066 citations , March 2010 in “Nature Reviews Molecular Cell Biology”

This review discusses the potential regulation of signal transduction pathways by microRNAs in animal cells, aiming to identify biological processes that may be influenced by miRNA-mediated regulation, but it reports no new experimental outcomes.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , November 2012 in “Stem cells”

This study reports that miR-302 promotes pluripotency by inhibiting NR2F2 and indirectly regulating OCT4 in stem cells, enhancing reprogramming efficiency when added to traditional factors.

research MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway

103 citations , November 2014 in “Journal of Cell Biology”

This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.

research Importance of microRNAs in skin morphogenesis and diseases.

70 citations , September 2008 in “PubMed”

This article reviews the role of microRNAs in skin-related conditions like psoriasis and wound healing and highlights their potential as therapeutic targets and diagnostic biomarkers, without reporting new experimental results.

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community MicroRNA science breakthrough? Softening stem cells

6 upvotes 3 years ago

A potential breakthrough in hair loss treatment involves softening hair follicle stem cells, but its effectiveness in humans is uncertain. Users express skepticism, noting past successes in mice that haven't translated to human treatments.

community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

community Recent trials investigating mesenchymal stem cell derived exosomes demonstrate significant increases in anagen duration and hair shaft caliber by upregulating Wnt/beta-catenin pathways.

4 upvotes 3 weeks ago

Exosomes from mesenchymal stem cells can increase hair growth by enhancing anagen duration and hair shaft thickness through the Wnt/beta-catenin pathway. Phase 2 trials show improved hair counts over 24 weeks.

community Is this regrowth? My doctor took these photos and said I looked better.

in Satire 142 upvotes 1 year ago

The conversation humorously discusses an extensive and exaggerated hair loss treatment regimen, including finasteride, dutasteride, minoxidil, pyrilutamide, RU58841, and various other therapies. Despite the numerous treatments, the effectiveness is questioned, and the user humorously considers adding more minoxidil.

community Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser

2 upvotes 2 years ago

Exosomes combined with fractional picosecond laser treatment were effective in treating androgenetic alopecia and promoting repigmentation in white hair patches. The role of exosomes in hair repigmentation, particularly in conditions like poliosis, is not well-studied.

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learn microbiota modulator

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