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Glossary MicroRNAs

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating gene expression by binding to messenger RNAs (mRNAs) and inhibiting their translation or promoting their degradation. In the context of hair loss and hair biology, miRNAs are involved in various processes such as hair follicle development, cycling, and the response to stressors that can lead to conditions like androgenetic alopecia. Key distinguishing characteristics of miRNAs include their ability to modulate multiple target genes simultaneously, which can influence cellular pathways related to hair growth and loss. Understanding the role of miRNAs in hair biology may offer insights into potential therapeutic targets for hair loss treatments.

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research MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives

June 2026 in “Frontiers in Cell and Developmental Biology”

This review outlines recent advancements in understanding how micro-RNAs (miRNAs) influence hair regeneration, highlighting their role in stimulating hair growth and potential therapeutic approaches, while also addressing the challenges of clinical translation due to miRNAs' complex roles and delivery issues.

research MicroRNA control of signal transduction

1066 citations , March 2010 in “Nature Reviews Molecular Cell Biology”

This review discusses the potential regulation of signal transduction pathways by microRNAs in animal cells, aiming to identify biological processes that may be influenced by miRNA-mediated regulation, but it reports no new experimental outcomes.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , November 2012 in “Stem cells”

This study reports that miR-302 promotes pluripotency by inhibiting NR2F2 and indirectly regulating OCT4 in stem cells, enhancing reprogramming efficiency when added to traditional factors.

research MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway

103 citations , November 2014 in “Journal of Cell Biology”

This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.

research Importance of microRNAs in skin morphogenesis and diseases.

70 citations , September 2008 in “PubMed”

This article reviews the role of microRNAs in skin-related conditions like psoriasis and wound healing and highlights their potential as therapeutic targets and diagnostic biomarkers, without reporting new experimental results.

research MicroRNA/mRNA regulatory networks in the control of skin development and regeneration

56 citations , February 2012 in “Cell Cycle”

This review discusses the role of miRNA/mRNA regulatory networks in skin development, epidermal homeostasis, and tissue remodeling, and suggests potential for miRNA-based therapies in treating skin conditions, but reports no new clinical results.

research MicroRNA Species in Follicular Fluid Associating With Polycystic Ovary Syndrome and Related Intermediary Phenotypes

50 citations , January 2016 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that miRNA expression profiles in follicular fluid are altered in women with PCOS, with certain miRNAs potentially useful for distinguishing patient subtypes and contributing to understanding PCOS heterogeneity.

research Control by a hair’s breadth: the role of microRNAs in the skin

41 citations , September 2012 in “Cellular and Molecular Life Sciences”

This review summarizes the current understanding of microRNAs in skin biology, highlighting their roles in processes like wound-healing and aging, without presenting any new experimental results.

research MicroRNAs in skin tissue engineering

39 citations , May 2015 in “Advanced drug delivery reviews”

This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.

research Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep

37 citations , October 2013 in “PLoS ONE”

This study provides new insights into the identification and expression patterns of miRNAs in wool follicles, which could improve understanding of wool follicle development in sheep.

research High-throughput sequencing of hair follicle development-related micrornas in cashmere goat at various fetal periods

33 citations , December 2017 in “Saudi Journal of Biological Sciences”

In this study, researchers found that microRNAs in the oar-let-7 and oar-miR-200 families were significantly up-regulated during critical fetal periods of cashmere goat hair follicle development, suggesting their role in this process.

research MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

32 citations , July 2017 in “Molecular diagnosis & therapy”

MicroRNA-21 could help diagnose and treat skin fibrosis.

MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration

research MicroRNAs in the skin: role in development, homoeostasis and regeneration

31 citations , July 2017 in “Clinical Science”

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

research MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis

29 citations , December 2021 in “Biomedicines”

This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.

Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

research Differential expression analysis of balding and nonbalding dermal papilla microRNAs in male pattern baldness with a microRNA amplification profiling method

29 citations , October 2011 in “British Journal of Dermatology”

This study found that four microRNAs, which were significantly upregulated in balding hair follicle papilla cells, could play a role in the development of male pattern baldness.

research MicroRNA in skin diseases

27 citations , July 2017 in “European Journal of Dermatology”

This article reviews the role of microRNAs as epigenetic modulators in dermatology but reports no new clinical findings.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

25 citations , September 2014 in “Biological Research”

This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.

research Current insight into the functions of microRNAs in common human hair loss disorders: a mini review

22 citations , April 2021 in “Human Cell”

MicroRNAs may help diagnose and treat hair loss disorders.

research An Integrated Analysis of MicroRNA and mRNA Expression Profiles to Identify RNA Expression Signatures in Lambskin Hair Follicles in Hu Sheep

22 citations , July 2016 in “PLoS ONE”

This study identified specific microRNAs and genes associated with the differing wave patterns in Hu sheep hair follicles, which may help understand the molecular mechanisms behind wool quality.

research Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone

22 citations , March 2012 in “Molecular Medicine Reports”

This study found that DHT treatment led to reduced cell growth, increased cell death, cell cycle arrest, ROS production, and senescence in normal human dermal papilla cells, potentially mediated by altered miRNA expression.

research MicroRNAs take part in pathophysiology and pathogenesis of Male Pattern Baldness

21 citations , October 2009 in “Molecular Biology Reports”

research Identification of ultraviolet B radiation-induced microRNAs in normal human dermal papilla cells

18 citations , July 2014 in “Molecular Medicine Reports”

This study found that UVB radiation significantly alters miRNA expression and induces cytotoxicity and apoptosis in normal human dermal papilla cells.

research Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging

16 citations , June 2019 in “Journal of Investigative Dermatology”

The researchers reported that miR-21 expression increases with age in both human and mouse skin and may contribute to skin aging by targeting the chromatin remodeler SATB1 in keratinocytes.

research Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

16 citations , January 2016 in “Annals of Dermatology”

This study suggests that epigallocatechin gallate (EGCG) from green tea may counteract DHT-induced hair follicle damage by modifying the miRNA expression profile in human dermal papilla cells.

research Identification of blood microRNA alterations in patients with severe active alopecia areata

15 citations , April 2019 in “Journal of Cellular Biochemistry”

This study identified specific miRNAs that are potentially linked to severe active alopecia areata, suggesting they could be targets for future treatment development.

Screening of MicroRNA and mRNA Related to Secondary Hair Follicle Morphogenesis and Development and Functional Analysis in Cashmere Goats

research Screening of microRNA and mRNA related to secondary hair follicle morphogenesis and development and functional analysis in cashmere goats

14 citations , April 2022 in “Functional & Integrative Genomics”

This study identified specific miRNAs and mRNAs involved in the development of secondary hair follicles in cashmere goats, particularly noting a targeted relationship between chi-miR-30e-5p and DLL4.

research The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

13 citations , September 2018 in “Scientific Reports”

In this study, researchers found that microRNAs and specific target genes, such as MiR-195 and genes like CHP1, SMAD2, FZD6, and SIAH1, play significant roles in regulating hair follicle initiation in cashmere goats.

research Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients

12 citations , November 2020 in “Journal of Dermatological Science”

In this study, miR-324-3p was found to promote differentiation and migration in cultured keratinocytes and is highlighted as a potential target for treating androgenic alopecia.

research EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

12 citations , July 2020 in “Aging”

This study found that the enhancer of zeste homolog 2 (EZH2) may promote hair growth by increasing STK40 expression and facilitating hair follicle stem cell proliferation and differentiation.

Analysis of Changes in MicroRNA Expression Profiles in Response to the Troxerutin-Mediated Antioxidant Effect in Human Dermal Papilla Cells

research Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells

12 citations , May 2015 in “Molecular Medicine Reports”

This study demonstrated that troxerutin may protect human dermal papilla cells from H2O2-induced damage and suggests potential in treating alopecia by inhibiting ROS-mediated cellular damage.