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GlossaryMendelian randomization

uses genetic variations to infer causal relationships in biology

Mendelian randomization is a research method that uses genetic variations to study the causal effects of a modifiable exposure (like diet or lifestyle) on a disease. By leveraging the random assortment of genes from parents to offspring, it mimics the design of a randomized controlled trial, helping to determine whether an observed association between a risk factor and a health outcome is likely to be causal rather than due to confounding factors.

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Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations , December 2018 in “PLOS Genetics”

The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.

research Mendelian Randomization Analysis of the Causal Relationship Between Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Androgenic Alopecia

January 2026 in “Medicine”

Higher LDL cholesterol may increase the risk of hair loss, while HDL cholesterol does not.

research Exploring the Link Between Gut Microbiota and Alopecia Areata: A Two-Sample Mendelian Randomization Analysis

6 citations , January 2024 in “International Journal of Dermatology”

Certain gut bacteria may cause alopecia areata.

research The Causal Relationship Between Gut Microbiota and Alopecia Areata: A Mendelian Randomization Analysis

5 citations , July 2024 in “Frontiers in Microbiology”

Changes in gut bacteria might influence alopecia areata.

research The Causal Relationship Between Androgenetic Alopecia And Serum Uric Acid: A Bidirectional Mendelian Randomization Analysis

1 citations , August 2024 in “Skin Research and Technology”

There is no causal relationship between androgenetic alopecia and serum uric acid.

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community Hair Loss Causes Depression. Not Finasteride.

in Research/Science 188 upvotes 1 month ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.

community Hair Loss Ruins Your Mind: 10x rate of BDD. PF S is not real

in Research/Science 39 upvotes 1 month ago

Hair loss is linked to a higher rate of body dysmorphic disorder (BDD), OCD, and depression. Finasteride and dutasteride are not linked to increased suicidal risk, though some users report mental health side effects.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.