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GlossaryMendelian randomization

uses genetic variations to infer causal relationships in biology

Mendelian randomization is a research method that uses genetic variations to study the causal effects of a modifiable exposure (like diet or lifestyle) on a disease. By leveraging the random assortment of genes from parents to offspring, it mimics the design of a randomized controlled trial, helping to determine whether an observed association between a risk factor and a health outcome is likely to be causal rather than due to confounding factors.

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Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations, December 2018 in “PLOS Genetics”

The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.

research Roles of Gut Microbiota in Androgenetic Alopecia: Insights from Mendelian Randomization Analysis

April 2024 in “Frontiers in microbiology”

Certain gut bacteria may increase or decrease the risk of male pattern baldness.

Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis

research Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis

February 2025 in “Clinical Cosmetic and Investigational Dermatology”

Higher fasting insulin levels increase the risk of androgenetic alopecia.

research Does Androgenic Alopecia Aggravate the Risk of Prostate Cancer? Evidence from Mendelian Randomization

April 2024 in “Prostate international”

Male pattern baldness does not cause an increased risk of prostate cancer.

Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

4 citations, January 2023 in “Frontiers in Immunology”

Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 864 upvotes 4 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.