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Glossary Melanoma-Associated Antigen

proteins found in tumors, aiding cancer immunotherapy research

Melanoma-Associated Antigen (MAGE) refers to a group of proteins that are typically expressed in various types of tumors, including melanoma, but are not usually found in normal tissues except for the testis and placenta. These antigens are important in cancer research and immunotherapy because they can serve as targets for immune system-based treatments, helping the body to recognize and attack cancer cells.

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Research

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research Regulatory pathway analysis of coat color genes in Mongolian horses

14 citations , September 2017 in “Hereditas”

This study found that differentially expressed genes in horses with white versus black coats may regulate coat color, providing insights into the genetics of skin melanin synthesis.

research 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

13 citations , March 2020 in “Frontiers in cell and developmental biology”

This study suggests that 3,4,5-tri-O-caffeoylquinic acid activates β-catenin to enhance pigmentation in mouse hair follicles, human melanocytes, and melanoma cells during the hair cycle's growth phase.

research Associations between sun sensitive pigmentary genes and serum prostate specific antigen levels

4 citations , March 2018 in “PloS one”

This study found that among men over 70, certain genetic variants associated with skin pigmentation affect serum PSA levels, with implications for how sun sensitivity and exposure may influence prostate cancer risk.

research Association between VDR Gene Polymorphisms and Melanoma Susceptibility in a Colombian Population

5 citations , January 2022 in “Asian Pacific Journal of Cancer Prevention”

This study found that the rs2228570 polymorphism of the VDR gene was associated with an increased risk of melanoma, while the rs731236 polymorphism was linked to a protective effect against the disease in Colombian patients.

research Spectrum of Phenotypes Associated with Human MC1R Variations

June 2025 in “Albus Scientia”

This review discusses the role of the MC1R gene in human pigmentation and its genetic variants, reporting no new results; the authors highlight its forensic applications for phenotypic prediction.

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Community Join

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community Male pattern baldness is not cosmetic.

224 upvotes 9 months ago

Male pattern baldness is linked to health risks and should be treated medically. Finasteride is effective and should be insurance-covered.

community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community The Health Benefits of Head Hair

in Research/Science 19 upvotes 11 months ago

Hair provides protection against head trauma, reduces skin cancer risk, helps remove heavy metals, and aids in wound healing. The conversation emphasizes the health benefits of maintaining head hair beyond cosmetic reasons.

community When you start balding you notice how unnatural this phenomenon is

532 upvotes 1 year ago

Hair loss is a common issue, with treatments like finasteride and minoxidil used but not as permanent cures. Frustration exists over societal perceptions and the lack of a definitive solution.

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Experts

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

Clinics

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Hair Loss TreatmentsDermatology
Associated Dermatologists | BerkleyBerkley, MI · US

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Jane Genesi