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research Polymorphisms in androgen and estrogen receptor genes: effects on male aging

12 citations , October 2004 in “Experimental Gerontology”

This review summarizes how common polymorphisms in androgen and estrogen receptor genes may influence aging-related symptoms and diseases in men, but it reports no new clinical results.

research Advances in male hormone substitution therapy

23 citations , August 2005 in “Expert opinion on pharmacotherapy”

This review examines the benefits and potential risks of androgen replacement therapy for male hypogonadism but reports no new clinical results; the authors highlight the need for careful risk assessment, especially in older men.

research Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies

15 citations , June 2020 in “Experimental Dermatology”

This review discusses recent genetic findings on hormonal signaling pathways in androgenetic alopecia, reporting no new study results but highlighting the need for further investigation.

Corticotropin Releasing Factor-1 Receptor Antagonism Associated With Favorable Outcomes of Male Reproductive Health Biochemical Parameters

research Corticotropin releasing factor-1 receptor antagonism associated with favorable outcomes of male reproductive health biochemical parameters

May 2023 in “Frontiers in Endocrinology”

This study found that tildacerfont treatment in males with congenital adrenal hyperplasia reduced androgen levels and improved markers of testicular function, suggesting potential benefits for male reproductive health.

research Age‐dependent regulation by androgens of gene expression in the anterior hypothalamus and stress‐induced release of adrenal hormones in adolescent and adult male rats

10 citations , March 2019 in “Journal of neuroendocrinology”

This study found that developmental changes in testosterone synthesis and gene regulation may explain age differences in corticosterone release in response to stress between adolescent and adult rats.

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community 3 months on finasteride + minoxidil after hormone crash

in Is this regrowth? 8 upvotes 4 months ago

A 29-year-old male experienced hair loss and reduced libido after heavy drinking from 2020 to 2024, and began using finasteride (1mg daily) and minoxidil (5% topical, once daily) in January 2026, noticing thicker hair but no new regrowth after three months. He also introduced derma rolling in February and plans to continue treatment for 6–12 months before fully assessing results.

community Should I start Fin with these blood tests?

18 upvotes 3 years ago

A 25-year-old male with normal hormone levels is considering starting finasteride and minoxidil for hair loss but is concerned about high estradiol levels and potential side effects. Responses vary, with some suggesting blood tests before starting treatment and others emphasizing individual tolerance and the importance of consulting a doctor.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.