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    Glossary Prostate Cancer Prevention Trial

    large-scale study testing finasteride's effect on prostate cancer risk

    The Prostate Cancer Prevention Trial (PCPT) was a large-scale clinical study aimed at determining whether the drug finasteride could reduce the risk of prostate cancer in men. Conducted by the National Cancer Institute, the trial found that finasteride significantly lowered the incidence of prostate cancer, although it also raised concerns about an increased risk of high-grade tumors.

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    1. Bicalutamide Nonsteroidal anti-androgen, originally a prostate cancer drug
    2. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    3. Mesotherapy Injections of drug or vitamin mixtures into the scalp
    4. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    5. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically