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    GlossaryIn Vitro Tests (laboratory tests)

    experiments conducted outside living organisms in controlled environments

    In vitro tests are experiments conducted outside of a living organism, typically in a controlled laboratory environment such as a test tube or petri dish. These tests allow researchers to study biological processes, drug effects, or chemical reactions in isolation, providing valuable insights without the complexity of a whole living system.

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      community Possible solution: 2.5mg DUT for everyone

      in Chat  14 upvotes 10 months ago
      A user is experimenting with creating a DIY oral Dutasteride solution using raw powder, MCT oil, and Vitamin E to reduce costs. Others discuss their experiences with similar methods and the challenges of sourcing and testing Dutasteride.

      community NEW Creatine and DHT/Hairloss Study

      in Research/Science  9 upvotes 10 months ago
      Creatine is believed by some users to cause hair shedding, though a study found no increase in DHT or testosterone levels. Many users shared personal experiences of hair loss after using creatine, while others noted no change, suggesting individual variability.

      community What can be the real reason of Finasteride SE ?

      in Finasteride/Dutasteride  19 upvotes 8 months ago
      Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.