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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    Research 10 of 1000+

    1. <i>In‐silico</i> Screening of ATP‐competitive Inhibitory Activities of Phytochemicals against Janus Kinase 3 and Its <i>In‐vitro</i> Evaluation ˜The œFASEB journal · 2020
    2. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    3. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    4. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    5. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    6. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    7. Janus kinase inhibitors for alopecia areata Journal of the American Academy of Dermatology · 2023 · 7 citations
    8. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    9. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    10. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
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