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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    Research 30 of 1000+

    1. <i>In‐silico</i> Screening of ATP‐competitive Inhibitory Activities of Phytochemicals against Janus Kinase 3 and Its <i>In‐vitro</i> Evaluation ˜The œFASEB journal · 2020
    2. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    3. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    4. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    5. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    6. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    7. Janus kinase inhibitors for alopecia areata Journal of the American Academy of Dermatology · 2023 · 7 citations
    8. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    9. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    10. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    11. 44182 Treatment with Oral Janus Kinase Inhibitors in Adults Patients with Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    12. LB785 Efficacy and safety of baricitinib in adults with Alopecia Areata: Phase 3 results from a randomized controlled trial (BRAVE-AA1) Journal of Investigative Dermatology · 2021 · 3 citations
    13. Olumiant® (Baricitinib)-A Newly Approved Janus Kinase Inhibitor for the Treatment of Alopecia Areata. PubMed · 2022
    14. 32237 Clinician and patient evaluation of improvement for eyebrow and eyelashes hair loss during baricitinib phase 3 trials BRAVE-AA1 and BRAVE-AA2 Journal of The American Academy of Dermatology · 2022
    15. Exploring the efficacy of baricitinib in treating alopecia areata after failed Janus kinase inhibitor therapy JAAD Case Reports · 2023 · 7 citations
    16. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    17. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    18. Association of Janus kinase inhibitors with reduced depression in alopecia areata Journal of the European Academy of Dermatology and Venereology · 2025
    19. Discontinuation and restart of Janus kinase inhibitors due to pregnancy in alopecia areata: a case series International Journal of Women’s Dermatology · 2025
    20. Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials Postgraduate Medical Journal · 2025
    21. BH14 Irish dermatologists’ experience with Janus kinase inhibitors in alopecia areata British Journal of Dermatology · 2025
    22. Supplementary Material for: Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Figshare · 2018
    23. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    24. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018 · 66 citations
    25. BH20 An unintended sequela of hair regrowth: severe Janus kinase inhibitor-associated acneiform eruption in alopecia areata British Journal of Dermatology · 2026
    26. Public Interest in Janus Kinase (JAK) IInhibitors for Alopecia Areata: A Google Trend Analysis JMIR Dermatology · 2026
    27. SYSTEMATIC REVIEW OF ORAL JANUS KINASE INHIBITORS IN ALOPECIA AREATA: INSIGHTS FROM 2020 TO 2025 STUDIES International Journal of Innovative Technologies in Social Science · 2025
    28. Comparative Efficacy Evaluation of Alopecia Areata Management with Janus Kinase Inhibitors in Children: Retrospective Cohort Study Педиатрическая фармакология · 2025
    29. The Use of Janus Kinase Inhibitors for Primary Neutrophilic Cicatricial Alopecias International Journal of Trichology · 2025
    30. 151 Efficacy and adverse effects of oral Janus kinase inhibitor (JAKi) use in patients with lichen planopilaris: a retrospective case series and systematic review 2023