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research NEDD4 Transcript Variant 3 and IGF-1 as Molecular Markers in the Development and Prognosis of Keloids

January 2025 in “The Egyptian Journal of Hospital Medicine”

This study found that keloid patients exhibited significantly higher expression levels of NEDD4-TV3 and IGF-1 genes compared to controls, indicating a potential role of these genes in predicting and understanding keloid formation.

research The role of Paraoxonase 1 in Alopecia Areata, a Marker and a Severity Index

July 2022 in “International Journal of Contemporary Medicine”

This study found that patients with alopecia areata have significantly lower serum PON1 levels compared to controls, indicating a potential link between oxidative stress and the pathogenesis of the disease.

research Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture

15 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that erlotinib exacerbates inflammation in a mouse model of skin disease and that IL-1 inhibition could mitigate skin-related side effects of EGFR inhibitors.

research A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations

11 citations , March 2013 in “Gene”

This study reported that the IL1A 4-bp indel polymorphism is associated with a reduced risk of alopecia areata in Chinese populations, possibly through miR-122 mediated regulation of IL-1α expression.

research Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

1 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

In this study on cultured human dermal papilla cells, researchers found that niacinamide may enhance hair growth by reducing oxidative stress-induced cell senescence and delaying catagen entry, suggesting potential applications against hair loss.

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Community Join

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community How to increase Pyri concentration from 0.5% to 1% wihout using more volume ( 2ml x 2 per say for example )

in Chat 6 upvotes 2 years ago

OP wants to increase pyrilutamide concentration from 0.5% to 1% while already using finasteride. Users suggest waiting for a commercial 1% solution and caution against using grey market products.

community GT20029 Big Phase 2 Update Results!

53 upvotes 9 months ago

GT20029 showed promising results for hair growth in a Phase II trial, with the 1.0% twice-weekly regimen being the most effective. Some users expressed skepticism and humor about the product's effects and market availability.

community Why is Kopexil (trade name Aminexil) not approved as a drug in the US and Europe?

3 upvotes 10 months ago

Kopexil (Aminexil) is not approved as a drug in the US and Europe because it is marketed as a cosmetic, which requires less testing and regulation. L'Oreal's 1.5% Aminexil is noted to reduce hair shedding, but its efficacy as a drug is not proven.

community OND-1 "Cyclosporine A” New hair loss treatment

in Research/Science 28 upvotes 5 months ago

Orient Bio is developing a PLGA formulated version of Cyclosporine A to stimulate hair growth without its immunosuppressant effects. Users discuss various treatments like Clascoterone, PP405, minoxidil, and tacrolimus, expressing hope for new developments and sharing personal experiences with these treatments.

community [28M] 1 year and 5 months update

in Progress Pictures 5 upvotes 5 months ago

A user shared their 1 year and 5 months update on using finasteride and minoxidil for hair loss, noting improved hair density but a still receding hairline. They mentioned being inconsistent with minoxidil initially and experiencing more hair shedding after starting it.

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Learn

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learn Scalp Micropigmentation

What is Scalp Micropigmentation and how does it help people with visible hair loss? Scalp Micropigmentation creates the illusion of hair follicles on the scalp for visible hair loss.

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

What does finasteride do to the female body? Find out its side effects. Finasteride is not approved for hair loss in women anywhere; the one controlled trial, in 137 postmenopausal women at 1 mg daily, found no benefit over placebo, while smaller uncontrolled studies at higher off-label doses report some improvement. It is contraindicated in pregnancy and crushed or broken tablets must not be handled. Side effects in women are poorly described; in men the range of reported side effects is wider than sexual alone (mood and suicidal thoughts, cognitive complaints, breast and semen effects), some reported to persist after stopping.
Is finasteride safe? In one-year trials most men tolerated finasteride 1 mg, but its risks are not only sexual: US, UK and EU regulators warn of sexual dysfunction, depression and suicidal thoughts, and of sexual and mood symptoms that have continued after stopping, and men also report cognitive, anxiety and physical symptoms. How often lasting problems happen, and how much of that the drug causes, is not known; finasteride is prescription-only and must not be taken, or handled as crushed or broken tablets, by women who are or may be pregnant.

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

learn Follistatin

Protein that blocks activin, a growth-regulating signal

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Hair Transplant

Will people be able to tell I had a hair transplant? Clinics say a well-done transplant is often hard to notice once healed, but redness and scabs show for 1 to 2 weeks and results vary.

learn tamsulosin

What is tamsulosin and how is it used in treatments related to hair loss? Tamsulosin is a prescription alpha-1 blocker approved for benign prostatic hyperplasia; no human trial has tested it for hair loss, and there are no dosing protocols or safety data for that use. Its connection to hair is a receptor-biology hypothesis, not a treatment.

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