The Role of Paraoxonase 1 in Alopecia Areata: A Marker and a Severity Index

    July 2022 in “ International Journal of Contemporary Medicine ”
    Hamdy Omar, Nglaa Abd Allah, Sabah Ebrahim Abd Elrahim, Moshira Mohammed Ali
    TLDR Lower Paraoxonase 1 levels in alopecia areata patients suggest antioxidant treatment might help.
    The study investigated the role of Paraoxonase 1 (PON1) in alopecia areata (AA) by measuring serum PON1 levels in 30 AA patients compared to 30 controls. Results showed a significant decrease in PON1 levels in AA patients (54.083 ± 25.464 μg/L) compared to controls (69.479 ± 17.012 μg/L), with a more pronounced decrease in males. The findings suggested an association between oxidative stress and the pathogenesis of AA, indicating that reducing oxidative stress could be a potential therapeutic approach, and recommending the use of antioxidant drugs for treatment.
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