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Glossary Interleukin-1 Receptor Antagonist

naturally occurring protein that inhibits inflammatory molecule interleukin-1

Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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research Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article

1 citations , June 2022 in “The Egyptian Journal of Hospital Medicine”

This review discusses the epidemiology, clinical characteristics, pathogenesis, and genetic factors of alopecia areata, while stressing the need for targeted and effective treatments, but reports no new clinical results.

research THE PATHOGENESIS OF ALOPECIA AREATA

89 citations , October 1996 in “Dermatologic Clinics”

This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.

research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

In this mouse study, the researchers found that the monoclonal antibody ME1 causes hair follicle inflammation by up-regulating TNFα, which can be reduced by TNFα and interleukin-1 inhibitors.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle

14 citations , February 2021 in “Experimental Dermatology”

This study found that activating CB1 receptor signaling in human hair follicles increased stem cell proliferation while reducing differentiated cell survival, suggesting CB1's role as a survival stimulus for epithelial stem cells.

research Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?

19 citations , September 2008 in “Journal of Cellular Physiology”

This article explores potential mechanisms of acneiform skin eruptions linked to EGFR inhibition in cancer patients, focusing on EGFR's role in controlling IL-1-dependent inflammation at hair follicles, but reports no clinical results.

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community The 2026 Breakthrough Pipeline: Top 5 Mind-Changing Hair Loss Treatments To Watch

1 week ago

New hair loss treatments include lab-grown hair cloning, scarless healing with verteporfin, GT20029 for receptor degradation, JAK inhibitors for follicle activation, and dermal papilla stem cell exosomes. These aim to regenerate hair rather than just slow hair loss.

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Jane Genesi
Marlton, PA, United States

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Jane Genesi