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Glossary Immune-Mediated

immune system mistakenly attacks the body's own cells

Immune-mediated refers to conditions or diseases that are caused by abnormal activity of the immune system, where it mistakenly attacks the body's own cells and tissues. This can lead to various health issues, such as inflammation, tissue damage, and organ dysfunction. Examples include autoimmune diseases like rheumatoid arthritis and alopecia areata, where the immune system targets hair follicles, leading to hair loss.

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Research

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research The emergence of Alopecia Areata is not dependent on perforin-mediated cytolysis

May 2024 in “The Journal of Immunology”

This study found that in mice, perforin-mediated cytolysis by CD8 T cells is not necessary for the autoimmune attack on hair follicles in alopecia areata, suggesting other mechanisms are responsible for disease progression.

research Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing

34 citations , June 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.

research 120 Identification of post-translationally modified trichohyalin epitopes responsible for triggering autoimmunity in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

Trichohyalin in hair can trigger immune attacks in alopecia areata.

research Anti-Aging Medicine for Hair

May 2018 in “International journal of cell science & molecular biology”

This article discusses the biology of cosmetic aging and the chemical pathways involved, emphasizing research advancements that aid clinicians in rejuvenating skin and increasing scalp hair density, but it provides no new results.

research Immunohistochemical localization of TGF‐β in alopecia areata

July 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

TGF-β is found in hair follicles and may cause hair loss in alopecia areata.

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Learn

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learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Community Join

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community Regrowth with only Nizoral and Lifestyle Changes; focusing on scalp health & nervous system

89 upvotes 7 months ago

The user reported subtle hair regrowth by focusing on scalp health and lifestyle changes, using Nizoral shampoo and methods to reduce inflammation and cortisol, without using finasteride, minoxidil, or other common treatments. Opinions in the conversation varied, with some skeptical of the results and others acknowledging the potential benefits of addressing scalp health and inflammation.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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Clinics

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Hair Systems
AP Art Attack Hairsystem - ZweithaarspezialistDüsseldorf, Nordrhein-Westfalen · DE

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