20 citations,
December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”
Blocking IL-12/IL-23 does not help with hair loss in alopecia areata for mice or humans.
176 citations,
August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”
Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.
The conversation is about someone considering a hair transplant due to ineffective hair loss treatments, with suggestions ranging from trying a hairpiece to continuing with medications like finasteride and minoxidil, and waiting for new treatments. Some advise against a transplant due to the extent of hair loss and the cost, while others share different views on the effectiveness of transplants and non-surgical options.
A user's 12 month update on treatment for hair loss, which include oral dutasteride and minoxidil, topical RU88541 and minoxidil, microneedling with hyaluronic acid and FinDuta, experiencing no side effects, positive results and inspiring other users.
A user stopped using minoxidil after 10-12 years due to severe side effects like fluctuating blood pressure and chest pain, resulting in significant hair loss. Other users shared similar experiences, emphasizing health over hair and suggesting alternatives like finasteride, nanoxidil, and rosemary oil.
1 mg dutasteride may be sufficient for most people, with higher doses showing diminishing returns. Combining dutasteride with minoxidil and ketoconazole can enhance results, but oral minoxidil may cause side effects.
GT20029, a new hair loss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.