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research IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans

20 citations , December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

In this study, ustekinumab did not promote hair regrowth in human patients with alopecia areata or prevent disease development in an AA mouse model, suggesting limited efficacy for this treatment.

research Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism

68 citations , November 2015 in “The Journal of Allergy and Clinical Immunology”

In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.

research Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

278 citations , March 2013 in “Gut”

In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.

research 294 Extensive alopecia areata is reversed by IL-12/23p40 cytokine antagonism

April 2016 in “Journal of Investigative Dermatology”

In this study, three patients with extensive alopecia areata receiving ustekinumab treatment showed significant hair regrowth and decreased inflammation over 20 weeks, suggesting potential targeted treatment for this condition.

research Biomarkers of alopecia areata disease activity and response to corticosteroid treatment

65 citations , December 2015 in “Experimental dermatology”

This study found that both Th1 and Th2 immune responses, along with IL-23 and IL-32 cytokine pathways, are active in alopecia areata lesions, and corticosteroid injections significantly altered these immune markers.

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Experts

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Learn

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learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
When can I return to work after a hair transplant? Most patients can return to work within 2 to 7 days after a hair transplant.

learn Scalp Micropigmentation

How often do I need touch-ups for scalp micropigmentation? Touch-ups for scalp micropigmentation are typically needed every 12-18 months.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Community Join

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community [30M] Regenera Activ (7 Weeks) + Topical Dutasteride/Minoxidil (12 Weeks)

in Progress Pictures 187 upvotes 1 year ago

A 30-year-old man shared his positive experience with hair regrowth using Regenera Activ, topical Dutasteride, Minoxidil, and PRP over 12 weeks. He plans to continue with injectable Dutasteride and emphasizes the importance of starting treatment early to combat hair loss.

community After 6 Months adding Topical Fin to minoxidil. Trust the process, be patient!

in Progress Pictures 127 upvotes 1 year ago

After 6 months of adding topical finasteride to minoxidil, the user saw significant hair improvement, with noticeable results starting from the 5th month. The treatment included 5% minoxidil, 0.5 mg topical finasteride, and supplements like omega-3, minerals, and vitamins, with minimal side effects reported.

community Does 1mg dutasteride get you most of the way there?

in Finasteride/Dutasteride 13 upvotes 1 year ago

1 mg dutasteride may be sufficient for most people, with higher doses showing diminishing returns. Combining dutasteride with minoxidil and ketoconazole can enhance results, but oral minoxidil may cause side effects.

community Update - December 2024 to May 2026. Topical fin/min

973 upvotes 4 months ago

The user experienced significant hair regrowth using a nightly topical spray with 0.3% finasteride and 6% minoxidil, without side effects. Noticeable improvements were seen within three months, with continued progress over time.

community Is this Minoxidil good? France

in Product 6 upvotes 5 months ago

A 19-year-old in France is experiencing hair loss after COVID-19 and is using Minoxidil, considering Finasteride but facing challenges in obtaining it. Users discuss Minoxidil's effectiveness, potential issues like crystallization, and alternative products like Foligain.

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Clinics

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