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GlossaryHypothalamic Amenorrhea

disruption in brain function stops menstruation due to stress

Hypothalamic Amenorrhea (HA) is a condition where menstruation stops for several months due to a disruption in the normal functioning of the hypothalamus, a part of the brain that regulates reproductive hormones. This disruption can be caused by factors such as excessive physical stress, significant weight loss, or emotional stress, leading to a decrease in the release of gonadotropin-releasing hormone (GnRH) and subsequently affecting the menstrual cycle.

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research Reproductive Dysfunction in Women With Epilepsy: Recommendations for Evaluation and Management

107 citations, August 2002 in “Journal of Neurology, Neurosurgery, and Psychiatry”

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

research Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea

18 citations, January 2020 in “Journal of Clinical Research in Pediatric Endocrinology”

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

research Targets to Treat Androgen Excess in Polycystic Ovary Syndrome

14 citations, September 2015 in “Expert Opinion on Therapeutic Targets”

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

research Neuroendocrine Determinants of Polycystic Ovary Syndrome

19 citations, March 2022 in “International Journal of Environmental Research and Public Health”

Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.

research Polycystic Ovary Syndrome: Clinical Aspects

27 citations, April 1996 in “Baillière's clinical endocrinology and metabolism”

The document says that understanding the causes of PCOS is important for treatment, especially in distinguishing the syndrome from just having cystic ovaries, and that losing weight is key for obese women with PCOS.

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community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 7 upvotes 4 days ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 1 year ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 2 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 17 upvotes 2 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community Injecting estrogen for hairline regrow

in Chat 261 upvotes 1 month ago

A user plans to undergo a temporary MtF transformation to regrow hair, using estrogen, RU58841, and Dutasteride, then revert with testosterone. Many users criticize the plan, suggesting alternatives like hair transplants, and emphasize that estrogen is not a reliable solution for hair regrowth.

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