2 citations
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November 2014 in “International Scholarly Research Notices” This study concluded that while the terpenoid fraction of M. jalapa's root extract increased growth factor expression in wound healing, it may lead to hypertrophic scars by prolonging the proliferation phase.
21 citations
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December 2023 in “Bioengineering & Translational Medicine” This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.
January 2025 in “Open Medicine” This study found that high-concentration cell-free adipose extract effectively reduced collagen deposition and blood vessel formation in a rabbit ear model, showing promise for preventing and treating hypertrophic scars.
5 citations
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September 2023 in “Journal of Cosmetic Dermatology” This study found that c-Maf positive M2 macrophages may promote hypertrophic scar formation by enhancing the proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts through increased TGF-β1 expression.
1 citations
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May 2010 in “Chinese journal of plastic surgery” This study found higher expression of melatonin receptors in fibroblasts of human hypertrophic scars compared to normal skin, suggesting a possible link to scar development.
