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research Human long-term deregulated circadian rhythm alters regenerative properties of skin and hair precursor cells

9 citations , July 2018 in “European journal of dermatology/EJD. European journal of dermatology”

This study provides evidence that long-term deregulation of the circadian rhythm in humans affects the regenerative properties of skin and hair precursor cells by altering clock pathway protein expression.

research Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis

20 citations , June 2024 in “Journal of Autoimmunity”

This study found that in rheumatoid arthritis patients, inflammatory macrophages activate steroid metabolism to increase glucocorticoid and androgen production, which helps suppress inflammation and attenuate hyperproliferation in synovial fibroblasts, with notable disturbances seen in postmenopausal women due to diminished inactive steroid precursors.

research Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone

515 citations , April 2003 in “Endocrine Reviews”

This review discusses hormone replacement therapy for menopausal women, emphasizing DHEA's unique ability to convert into sex steroids only in targeted tissues, and reports no new clinical results.

research Diosgenin: Chemistry, extraction, quantification and health benefits

50 citations , December 2022 in “Food Chemistry Advances”

This review discusses diosgenin's potential benefits for several chronic diseases and emphasizes extraction and quantification techniques, but reports no clinical findings.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.

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Community Join

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community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 3 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community What happened to that guy who’s been drinking topical minoxidil?!

in Chat 217 upvotes 1 year ago

A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

community Help interpreting pre-fin bloodwork

12 upvotes 5 years ago

A 20-year-old male is unsure how to interpret his bloodwork results and whether he should take finasteride for hair loss. His bloodwork shows borderline high levels of albumin and testosterone, and high progesterone, but normal levels of other hormones.

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Learn

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learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Follistatin

Is follistatin safe for use in women or transgender individuals undergoing hormone therapy? No study has tested follistatin in women or transgender people on hormone therapy, and it has no approved human use or established dose; a 2023 study in 72 adolescents with PCOS found that the body's own follistatin rose on estrogen-containing contraceptives alongside less favourable metabolic markers, a correlation that does not show follistatin caused them. The published evidence does not support using it in this group.

learn Exosomes

What does Fluridil do on the scalp, and how does it block the DHT hormone? Fluridil is a topical anti-androgen sold in some European countries. One small 2002 trial led by its developer reported more hairs in the growth phase; it is not FDA-approved and the evidence is limited.

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Clinics

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