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research Canine Alopecia Secondary to Human Topical Hormone Replacement Therapy in Six Dogs

14 citations , February 2015 in “Journal of the American Animal Hospital Association”

This study reports that transdermal exposure to owners' topical hormone replacement therapy caused alopecia in six dogs, but the condition resolved after the therapy was discontinued.

research Finasteride Cream In Hirsutism

27 citations , January 2001 in “Endocrine Practice”

In this preliminary study, women with facial hirsutism treated with topically applied finasteride cream showed a significant decrease in hair growth and thickness compared to placebo, without adverse effects.

research Skin manifestations in adults with gender dysphoria on hormone treatment in the outpatient clinic of Hospital de San José, Bogotá—Colombia

December 2023 in “International Journal of Dermatology”

This study observed that among transgender adults undergoing hormone therapy, common skin issues were acne, androgenetic alopecia, and other conditions, highlighting the need for dermatologists in their care; this is noted as the first Colombian and Latin American study on this topic.

research A Topical Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Antagonist Stimulates Hair Growth in Mice

26 citations , December 2006 in “Endocrinology”

This study found that a topical cream containing PTH (7–34) significantly stimulated hair growth in hairless mice.

research Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – “Out of the Woods”

1 citations , August 2021 in “Canadian journal of neurological sciences”

This article offers HTML content and a downloadable PDF but does not provide an abstract or new findings for summary.

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Community Join

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community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 11 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

137 upvotes 11 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

community Out of nowhere while watching this documentary about hairtransplant

4 upvotes 3 weeks ago

Creatine may cause hair loss in people with genetic predispositions, but not everyone. The discussion also questions the link between creatine and hair loss, considering factors like gender and hormones.

community Estradiol mesotherapy / idea feedback

5 upvotes 1 year ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community Creatine’s link to accelerating hair loss. Does any one have any lab work showing creatine raising DHT levels?

9 upvotes 2 years ago

Creatine may increase DHT levels, potentially accelerating hair loss in those predisposed to male pattern baldness. Some users report no change in DHT when using creatine without training.

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Learn

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learn sh-Polypeptide-7

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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