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Depression, Higher Level of Tension Induction, and Impaired Coping Strategies in Response to Stress in Women with PCOS Correlate with Clinical and Laboratory Indices of Hyperandrogenism and Not with Central Obesity and Insulin Resistance

research Depression, higher level of tension induction, and impaired coping strategies in response to stress in women with PCOS correlate with clinical and laboratory indices of hyperandrogenism and not with central obesity and insulin resistance

August 2024 in “Archives of Women s Mental Health”

This study found that women with PCOS exhibited higher levels of depression, tension induction, and impaired stress coping strategies compared to healthy controls, with these psychological issues correlating with hyperandrogenism but not with central obesity or insulin resistance.

Connection Between Granulosa Cell Pyroptosis and Oocyte Endoplasmic Reticulum Stress in a Mouse Model of Polycystic Ovary Syndrome

research Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome

2 citations , November 2025 in “Journal of Ovarian Research”

This study found that in a mouse model of PCOS, high androgen levels caused pyroptosis in ovarian granulosa cells and increased ER stress in oocytes, reducing oocyte maturation rates, while treatment with CPA and DMF improved these rates.

Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , October 2020 in “Journal of ethnopharmacology”

This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.

research Evaluation of Paraoxonase 1 Serum Level in Male Androgenetic Alopecia Patients

October 2023 in “Benha Journal of Applied Sciences”

This study found that male patients with androgenetic alopecia had lower serum levels of the antioxidant enzyme paraoxonase 1 compared to healthy controls.

research The tail-tale of stress: an exploratory analysis of cortisol levels in the tail-hair of captive Asian elephants

5 citations , January 2021 in “PeerJ”

This study observed that high levels of immunoreactive cortisol in the tail hair of captive Asian elephants were often associated with stressful or distinct behavioral events, suggesting its potential for reconstructing their physiological history.

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community Has anyone with high prolactin taken meds to lower it and seen hair regrowth?

5 upvotes 8 months ago

High prolactin levels may contribute to hair loss, and some users suggest supplements like mucuna pruriens, vitamin B6, vitamin E, L-Tyrosine, L-Theanine, DIM, and Zinc to lower prolactin. Lifestyle changes to increase dopamine, such as reducing screen time and stress, are also recommended.

community Regrowth from just fin after high stress and SSRI side effects?

9 upvotes 5 years ago

A 22-year-old experienced significant hair loss due to high stress, SSRI side effects, and Androgenic Alopecia, and has seen some regrowth after starting finasteride and using ketoconazole shampoo. They are inquiring if continued use of finasteride and stress reduction alone can lead to further hair regrowth.

community My estrogen levels are obscene

6 upvotes 1 year ago

A 30-year-old male using finasteride for hair loss has high testosterone and estrogen levels but no side effects. He is advised to monitor hormone levels, consider dietary changes, and use additional treatments like vitamin D3, minoxidil, and dutasteride for hair growth.

community Creatine made all my high DHT symptoms return

82 upvotes 1 year ago

Creatine may increase DHT levels, potentially causing symptoms like acne, oily hair, and hair shedding. Users report mixed experiences, with some avoiding creatine due to hair loss concerns and others seeing no impact.

community Prolactin and E2 high after finasteride

18 upvotes 3 weeks ago

A user experienced libido issues after using finasteride for five months, with elevated prolactin and estradiol levels. The discussion includes differing opinions on whether these symptoms are due to hormonal imbalances or post-finasteride syndrome.

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