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Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation

65 citations , July 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that overexpression of Hoxc13 in GC13 mouse models affects hair follicle differentiation by interacting with medulla-specific genes, particularly Foxq1, suggesting a regulatory pathway for medulla differentiation.

research The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice

9 citations , June 1999 in “Journal of Investigative Dermatology”

This study observed hair-specific transcription of a reporter gene in transgenic mice, with increased expression after dexamethasone and ultraviolet B treatment.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

research Identifying critical cell types and gene regulatory pathways for hair and skin disease

July 2023 in “Nature Genetics”

Researchers identified key cell types and genes involved in hair and skin diseases.

research 1392 Activation of Id2 gene regulatory network ruling quiescence of hair follicle stem cells

April 2018 in “Journal of Investigative Dermatology”

In this study using a transgenic mouse model, Id2 overexpression in hair follicle stem cells prolonged quiescence by affecting gene expression, partly independent from BMP signaling.

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Community Join

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community I am about to cry, umI hate my gens

in Chat 58 upvotes 1 year ago

Hair loss affects confidence, with discussions on treatments like finasteride, minoxidil, and RU58841. Emphasis is placed on self-acceptance and building confidence beyond appearance.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community Dad told me he had found a "hair growth tonic" bottles from my grandpas drawers

in Chat 252 upvotes 1 year ago

The conversation discusses various hair loss treatments, including Minoxidil, Dutasteride, Finasteride, and Tretinoin, with users sharing personal experiences and side effects. It reflects on generational attitudes towards hair loss and the emotional impact of hair loss remedies.

community Mature hairlines in general and defining them

13 upvotes 5 years ago

A "mature hairline" is subjective and may not indicate future stability. Finasteride and minoxidil are suggested treatments for hair loss.

community Breezula 6 Month Topline Phase III Results Released

172 upvotes 9 months ago

Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.

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Learn

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Beta Polypeptide

learn tamsulosin

Is tamsulosin linked to hair thinning or hair improvement as a side effect? Published tamsulosin trials, the product label and regulatory reviews do not establish a link to hair thinning, and no controlled study supports it as a hair-growth treatment; scattered post-marketing reports of alopecia exist but are not evidence of cause.

learn Hair Transplant

Is a hair transplant in Turkey safe? Clinics in Turkey describe their own work as safe when it is done in a licensed clinic by an experienced surgeon, and they also agree that quality varies a lot between clinics. All of that comes from the clinics themselves rather than from independent regulator or complication data, so any judgement rests on the specific clinic and surgeon, not on the country.

learn Valproic acid

Why is valproic acid not considered a standard cosmetic ingredient despite its potential effects on hair growth? Valproic acid is not a standard cosmetic ingredient due to safety and regulatory concerns.

learn Scalp Micropigmentation

Is scalp micropigmentation safe? Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.

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Clinics

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All 68 clinic results →

Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas