This review discusses the hormonal impact on hairgrowth and the relationship between endocrine disorders and hair changes, reporting no new clinical results.
72 citations
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October 2009 in “The FASEB journal”
This study found that thyrotropin-releasing hormone (TRH) acts as a potent stimulator of hairgrowth in human scalp hair follicles, promoting elongation and prolonging the anagen phase.
17 citations
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April 2016 in “Journal of Investigative Dermatology”
This study found that the synthetic thyroid hormone receptor modulator KB2115 significantly prolonged the growth phase of human hair follicles in culture without altering mitochondrial activity, suggesting potential as a safer hair loss treatment compared to traditional thyroid hormones.
1 citations
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February 2022 in “Clinical, Cosmetic and Investigational Dermatology”
In this study, researchers found that the thyroxine receptor agonist TDM10842 accelerated the onset of anagen, a hairgrowth phase, in C3H mice, potentially through activation of the Wnt/beta-catenin and Hedgehog pathways, with Pclaf playing a key role in this process.
The conversation discusses using minoxidil and dutasteride for hairgrowth, with OP considering amino acids or growthhormone for better results. Another user inquires about the effectiveness of dutasteride.
The user shared a 4-month hairgrowth update using 1mg finasteride, 5mg liquid minoxidil, and hormone replacement therapy (HRT), reporting significant hair regrowth. They also use a derma stamp, scalp massages, and a DHT-blocking shampoo.
Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hairgrowth without disrupting the skin microbiome. sCD83 promotes hairgrowth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.
Poor sleep quality may affect hairgrowth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hairgrowth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.
A 47-year-old male experienced significant hair loss after losing 37 kg in 6 months on a low-carb diet and started taking biotin, zinc, iron, selenium, and spectral dcn-n. Replies suggest that while carbs are not directly needed for hairgrowth, they help regulate hormones and nutrient absorption, and rapid weight loss can also contribute to hair loss.
How does sh-Polypeptide-7 help stimulate hair follicle activity or reduce scalp inflammation?sh-Polypeptide-7 is the INCI name for a lab-made form of human growth hormone (somatotropin) — not EGF, which is sh-Oligopeptide-1. Growth hormone and IGF-1 signalling is documented in hair follicle biology, but there is no published human trial of sh-Polypeptide-7 applied to the scalp for hair growth or scalp inflammation.