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research 8 Hair follicles and associated glands as androgen targets

53 citations , May 1986 in “Clinics in endocrinology and metabolism”

This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.

research Long-term renewal of hair follicles from clonogenic multipotent stem cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

research Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells

56 citations , July 2005 in “Experimental Dermatology”

This study demonstrated that hair follicle-derived cells can induce hair follicle formation in an in vitro skin organ culture system using human retroauricular skin specimens.

research Characterization of Hair Follicle Development in Engineered Skin Substitutes

41 citations , June 2013 in “PLOS ONE”

This study demonstrated that engineered skin substitutes using human keratinocytes and murine dermal papilla cells can develop pigmented hairs without sebaceous glands, suggesting separate pathways for hair development and eruption.

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community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Dht kills hair, but no one says why?

in Finasteride/Dutasteride 40 upvotes 1 year ago

DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

community Hot weather causing hair shedding?

3 upvotes 9 months ago

Hot weather can increase hair shedding, possibly due to dehydration and active sebaceous glands. Using shampoos with salicylic acid or zinc pyrithione may help; daily anti-inflammatory use is not recommended.

community Is this true? It can be a major breakthrough

1008 upvotes 5 months ago

Deoxyribose sugar gel may stimulate hair regrowth similarly to minoxidil by enhancing blood supply and follicle activity. Human trials are necessary, and current products have mixed results.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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Learn

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learn Salicylic acid

Does salicylic acid help clean and unclog hair follicles, and does that help hair growth? Salicylic acid loosens dead skin and oil on the scalp and is used in dandruff shampoos. No controlled study has shown that it helps hair grow.

learn Centella

Could nightly oil treatments with centella wake up sleeping follicles? There is no human evidence that centella oil wakes up dormant hair follicles; the only hair-related study is in cultured cells. Community users mention centella as a soothing ingredient, not a regrowth treatment.

learn Peppermint

herb and oil thought to stimulate skin and hair

Which is more effective: peppermint essential oil or extract in shampoo? Neither form has been tested for hair loss in people. Peppermint essential oil is the only one with any experimental support — a single four-week mouse study in which 3% peppermint oil outperformed 3% minoxidil on follicle counts — while peppermint extract in shampoo is a low-concentration cosmetic ingredient with no hair-growth data.

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Lavender

Plant essential oil used in scalp products

learn Niacinamide

Does niacinamide support hair follicle nutrition? Niacinamide is a precursor of NAD+, a molecule cells use for energy. Whether it affects hair follicles in people has not been tested.

learn Sulforaphane

Can sulforaphane protect hair follicles from inflammation and damage? In lab and mouse studies, sulforaphane reduced markers of inflammation and oxidative stress. No human study has tested whether it protects hair follicles.

learn Hair Transplant

Surgery that moves hair follicles from the back of the scalp to thinning areas

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Clinics

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas