31 citations
,
August 2021 in “Stem Cell Research & Therapy”
This review examines the life cycle, biomarkers, and functions of hairfollicle stem cells, emphasizing their role in hair loss therapy and other skin and hair disorders, but reports no new clinical results.
In this study, researchers observed that apoptosis occurs in both growing and regressing hairfollicles in dogs, indicating a spatio-temporal relationship with the hair cycle.
April 2023 in “Journal of Investigative Dermatology”
This study found that blocking apoptosis during the catagen phase in mice disrupts hairfollicle stem cell niche architecture, delaying subsequent hair regeneration cycles.
36 citations
,
July 2004 in “Journal of Controlled Release”
This study demonstrates that confocal laser scanning microscopy can effectively visualize the rapid diffusion and penetration pathway of a dye into the hairfollicle in fresh human scalp skin.
Microneedling at depths greater than 0.6 mm may damage miniaturized hairfollicles, with 0.5 mm showing better results for hair regrowth. Combining microneedling with minoxidil enhances absorption, but caution is advised to avoid damaging follicles.
Microneedling can cause hair shedding due to follicle puncturing, especially when using a 1mm depth. Users suggest using a dermastamp with a depth of 0.6-1mm and caution against home microneedling to avoid damaging hairfollicles.
Microneedling is unlikely to damage existing hair if done with a device using a smaller needle count, like a 9-needle cartridge, and a stamping motion. Hairfollicles are deeper than the typical needle penetration depth.
Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hairfollicles and preventing cell death, offering a localized treatment without systemic side effects.
Matrixyl 3000 is discussed as a potential topical treatment for hair growth, but concerns are raised about excess collagen production being a consequence of hair loss. The conversation suggests that androgen-induced miniaturization leads to hairfollicledeath and skin fibrosis.