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research Establishment of Heat‐Damaged Model for Hair

July 2025 in “Journal of Cosmetic Dermatology”

This study established a model of heat-damaged hair to assess hair care products, finding that daily hair drying for a month causes notable cuticle lifting, reduced mechanical properties, and increased protein release, and the model simulates even more severe damage.

Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

research Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

January 2024 in “GeroScience”

This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.

Eucommia Ulmoides Bark Extract Attenuates Oxidative Damage and H2O2-Induced Hair Follicle Suppression in Cellular and Mouse Models

research Eucommia ulmoides Bark Extract Attenuates Oxidative Damage and H2O2-Induced Hair Follicle Suppression in Cellular and Mouse Models

August 2026 in “Molecules”

This study found that Eucommia ulmoides bark extract shows potential antioxidant and hair follicle-support properties in vitro and in vivo, but further validation is needed to confirm these effects.

research Disruption of microtubules with low intensity ultrasound rescues hair follicle damage by paclitaxel in mouse models

July 2026 in “Nature Communications”

This study reports that brief exposure to low intensity and low frequency ultrasound was able to transiently break cellular microtubules and mitigate hair follicle damage, suggesting a potential method to prevent hair loss during chemotherapy with taxanes like paclitaxel.

Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

research Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model

12 citations , December 2017 in “Food and chemical toxicology”

This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.

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Community Join

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community Proposed new pathogenesis model for androgenetic alopecia (AGA)

7 upvotes 3 years ago

The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 2 years ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Sudden hair loss at month 10 of Fin/Min. Dermaroller and Dutasteride?

1 upvotes 4 days ago

The user experienced sudden hair loss after 10 months of using Minoxidil and Finasteride, possibly due to gastrointestinal issues affecting absorption. They started using a dermaroller and Dutasteride, and are concerned about potential damage and side effects.

community The Ultimate Guide to growing your hair back (revised).

in Treatment 161 upvotes 1 year ago

Hair loss treatments include using finasteride, dutasteride, and RU58841. Lifestyle changes like increasing carb intake and moderate alcohol consumption are suggested to boost estrogen levels.

community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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Learn

10 / 66 results

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Scalp micropigmentation does not damage existing hair or follicles.

learn Vitis vinifera

Does Vitis vinifera help protect hair follicles from damage? Vitis vinifera may protect hair follicles due to its antioxidant properties.

learn Sulforaphane

How does sulforaphane help protect hair follicles from inflammation and damage? Sulforaphane may protect hair follicles by reducing inflammation and oxidative stress.

learn L-cysteine

Can topical products with L-cysteine repair damaged hair or prevent breakage? Topical L-cysteine cannot effectively repair damaged hair or prevent breakage.

learn Ketoconazole

Ketoconazole: Is it safe to use every day or can it damage my hair? Ketoconazole shampoo is labelled for use about two to three times a week, and no published trial has tested daily use for hair loss; dermatology guidance and the product label warn that more frequent use tends to dry and irritate the scalp.

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Clinics

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All 70 clinic results →

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas