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Did you mean Genomic Instability?

Glossary Genomic Instability

increased tendency of DNA to acquire mutations

Genomic instability refers to an increased tendency of an organism's DNA to acquire mutations, which can lead to various genetic disorders, including cancer. For a layperson, it's like having a book where the words and sentences keep changing, making it hard to understand the original story. For professionals, it involves mechanisms such as DNA replication errors, defective DNA repair, and chromosomal rearrangements.

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Research

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research Safe Selection of Genetically Manipulated Human Primary Keratinocytes with Very High Growth Potential Using CD24

25 citations , August 2007 in “Molecular Therapy”

This study found that using ectopic expression of CD24 is a promising approach for selecting genetically modified human epidermal stem cells for safe cutaneous gene therapy in cancer-prone conditions.

Impact of Biomarkers in Predicting Response to Adjuvant Chemotherapy and Overall Survival in Females with Breast Cancer: A Review

research IMPACT OF BIOMARKER IN PREDICATIVE TO RESPONSE ADJUVANT CHEMOTHERAPY AND OVERALL SURVIVAL IN FEMALES INFECTED WITH BREAST CANCER: A REVIEW ARTICLES

March 2025 in “MINAR International Journal of Applied Sciences and Technology”

This study reviewed evidence on the role of specific genes (FKBP12, SAMAHD1, TRF2, CD155, and GATA3) in predicting how breast cancer patients might respond to adjuvant chemotherapy, aiming to monitor these markers in blood or tissue samples.

research The character “hairless” in the mouse

35 citations , November 1931 in “Journal of Genetics”

Hairless mice lack fur due to a genetic mutation affecting skin response, not hormone issues.

research Deciphering principles of morphogenesis from temporal and spatial patterns on the integument

19 citations , April 2015 in “Developmental Dynamics”

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

research Booby Trap: Cancer gene spurs production of DNA-assaulting chemicals that alert and defuse rescue molecule (Cancer; Oxidative damage)

June 2002 in “Science of aging knowledge environment”

This study suggests that the oncogene c-Myc can induce DNA damage by increasing reactive oxygen species, potentially overriding p53 and contributing to genetic instability in cancer cells.

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Community Join

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community DNA Testing by Roots by Genetic Arts

4 upvotes 2 years ago

A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

community How do you think Shah Rukh Khan maintains his full head of hair at 60?

453 upvotes 9 months ago

Shah Rukh Khan's hair at 60 is attributed to genetics, with speculation about using finasteride, minoxidil, or hair transplants. Some believe it's due to good genes, while others think he might use treatments or have had hair procedures.

community Balding Sucks. Balding Young is Awful. Balding Young and being Unable to Grow any Facial Hair is Hell on Earth

in Update 339 upvotes 1 year ago

A 25-year-old is frustrated with hair loss and inability to grow facial hair despite using oral finasteride and minoxidil for over a year. Suggestions include trying topical treatments, considering a hair system, or seeking professional help for mental health.

community Minoxidil Sulfate makes everyone a responder

258 upvotes 1 year ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community 15yo with severe anxiety from Norwood 2.5 and thinning

in Finasteride/Dutasteride 15 upvotes 1 year ago

A 15-year-old experiencing hair loss and anxiety is using minoxidil and microneedling but is advised against starting finasteride or dutasteride due to age. The discussion emphasizes consulting a doctor, considering hormonal evaluations, and exploring non-medication coping strategies.

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Learn

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learn Overview

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

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