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GlossaryForkhead box proteins (Forkhead box transcription factors)

transcription factors regulating gene expression in various processes

Forkhead box proteins, often abbreviated as FOX proteins, are a family of transcription factors that play crucial roles in regulating the expression of genes involved in various biological processes, including cell growth, differentiation, and longevity. They are named for their distinct DNA-binding domain, which resembles the shape of a forkhead. These proteins are essential for normal development and function, and mutations in FOX genes can lead to a variety of diseases, including cancer and developmental disorders.

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Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

93 citations, January 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

69 citations, January 2013 in “Frontiers in Immunology”

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

66 citations, January 2017 in “Acta dermato-venereologica”

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

21 citations, November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

research Transcriptional Regulation of the Thymus Master Regulator Foxn1

6 citations, August 2022 in “Science immunology”

Foxn1 gene regulation is crucial for thymus development but not for hair growth.

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community Rob Holding hair transplant looks unbelievable

in Transplants 600 upvotes 1 year ago

Rob Holding's hair transplant, which looks great despite the edited image of it; many respondents discussed their opinions on the hairstyle, while others suggested treatment options like Minoxidil and Finasteride.

community Oral min 2.5mg closing in on 3 months

in Progress Pictures 372 upvotes 1 year ago

_the_orange_box_'s experience using oral minoxidil, with discussion about finasteride and the potential side effects of both treatments. Other users shared their own experiences related to hair loss treatments.

community Is topical Minoxidil not meant for frontal baldness?

in Minoxidil 93 upvotes 1 year ago

The effectiveness of topical Minoxidil for frontal baldness and the differences between brands. Suggestions are made to use Finasteride and RU58841 in combination with Minoxidil to help treat hair loss.

community drinking topical minoxidil – extreme hair growth everywhere

in Minoxidil 396 upvotes 2 years ago

At this point. In this conversation, users discussed the risks of drinking topical minoxidil and suggested alternative treatments such as obtaining a prescription for oral minoxidil or finasteride.

community 9 months oral min, 2 months topical min. Late 30s.

in Progress Pictures 55 upvotes 4 months ago

The user used oral finasteride, topical minoxidil foam, a derma roller, keto shampoo, Hims thick fix shampoo, hair dye, and rosemary oil for hair restoration. They reported no side effects and noted significant improvement, especially in the hairline.

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