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GlossaryForkhead box proteins

transcription factors regulating gene expression in various processes

Forkhead box proteins, often abbreviated as FOX proteins, are a family of transcription factors that play crucial roles in regulating the expression of genes involved in various biological processes, including cell growth, differentiation, and longevity. They are named for their distinct DNA-binding domain, which resembles the shape of a forkhead. These proteins are essential for normal development and function, and mutations in FOX genes can lead to a variety of diseases, including cancer and developmental disorders.

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research Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

20 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

Reactive oxygen species (ROS) influence hair growth by causing DNA damage, cell death, and changes in immune cells.

research Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress During Hair Cycling

22 citations , July 2015 in “PloS one”

Foxp1 helps control hair stem cell growth and response to stress during hair growth cycles.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations , December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

188 citations , March 2018 in “Frontiers in Immunology”

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

research Investigating the Mechanisms Underlying the Pathogenesis of Alopecia Areata

May 2018 in “White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)”

Alopecia areata may be treated by using EGCG to balance immune cells and reduce inflammation.

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