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Glossary Wnt expression

activity of genes crucial for cell signaling and hair growth

Wnt expression refers to the activity of a group of genes known as Wnt genes, which produce proteins that play a crucial role in cell signaling pathways. These pathways are essential for regulating cell growth, development, and differentiation, including the growth of hair follicles. In the context of hair biology, proper Wnt expression is necessary for the normal cycling and regeneration of hair.

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research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

297 citations , January 2002 in “Development”

In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

research Expression of epidermal keratins and filaggrin during human fetal skin development.

292 citations , October 1985 in “The Journal of Cell Biology”

This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.

research Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis

252 citations , March 1998 in “Developmental dynamics”

This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.

research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

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community Effect of melatonin on aromatase expression

4 upvotes 4 years ago

Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.

community Pyrilutamide / KX-826 | Discussion EU

4 upvotes 3 years ago

The conversation is about a user expressing concerns over the safety of a new drug called Pyrilutamide (also known as KX-826) for hair loss. The user will only trust the drug if it's permitted by EU regulations and sold by a reputable company.

community Some men drown while others die of thrist

4403 upvotes 9 months ago

Men discuss hair loss, expressing frustration and humor about DHT sensitivity and alopecia. They mention treatments like Minoxidil, finasteride, and RU58841, and share personal experiences with hair loss and appearance.

community Why dont we research more on body hair

in Chat 32 upvotes 6 months ago

Body hair is more resilient than scalp hair due to different gene expressions and DHT sensitivity. Treatments like minoxidil and finasteride are used for hair loss, but they have varying effects on body and scalp hair.

community Is it worth giving dut 18/24 months if you haven't seen results after a year?

8 upvotes 1 month ago

The conversation discusses the effectiveness of dutasteride and finasteride for hair loss, with the original poster expressing concern over worsening hair loss despite long-term use. Users suggest that if no improvement is seen after 12-18 months, it may be time to reconsider the treatment, and some question the possibility of other underlying causes or the quality of the medication.

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