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Glossary Selective Estrogen Receptor Modulators

modulate estrogen effects in different tissues selectively

Selective Estrogen Receptor Modulators (SERMs) are a class of compounds that act on the estrogen receptor. They can either block or activate estrogen's effects in different tissues, depending on the specific SERM and the tissue type. For example, they might block estrogen's action in breast tissue to reduce the risk of breast cancer, while activating it in bone tissue to help maintain bone density.

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Research

5 / 1000+ results

research Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators

67 citations , January 2007 in “Climacteric”

This article discusses the impact of estrogens on skin aging, highlighting the potential benefits and unresolved effectiveness of alternatives like phytoestrogens and selective estrogen receptor modulators; it reports no new clinical results.

Pharmacological Activation of Estrogen Receptors-α and -β Differentially Modulates Keratinocyte Differentiation with Functional Impact on Wound Healing

research Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing

23 citations , September 2015 in “International Journal of Molecular Medicine”

This study found that the activation of ER‑β increased keratinocyte proliferation and gene expression related to epidermal regeneration, enhancing wound healing in both cell models and rats.

research The Effects of Estradiol, Androgens and the Selective Estrogen Modulators: Ospemifene, Raloxifene and Tamoxifen on Explant Cultures of Human Breast Tissue

May 2013 in “UTUPub (University of Turku)”

This study suggests that adding androgens to menopausal hormone therapy may reduce breast cancer risk by counteracting estrogen-driven proliferation in postmenopausal breast tissue.

research Biology of estrogens in skin: implications for skin aging

187 citations , December 2005 in “Experimental Dermatology”

This article discusses the role of estrogens in skin aging and reports no new findings; it highlights the potential of selective ER modulators to improve skin health without systemic side effects.

research The role of estrogen in cutaneous ageing and repair

158 citations , June 2017 in “Maturitas”

This review discusses the role of estrogen deficiency in post-menopausal skin aging and wound healing, highlighting opportunities for developing estrogen receptor-targeted therapies and reports no new clinical results.

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Community Join

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community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 7 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Best, possible, or experimental growth agonists that AREN'T MINOXIDIL.

4 upvotes 5 years ago

Various hair growth treatments were discussed, including microneedling, bimatoprost, setipiprant, stemoxydine, PGE2, CB-03-01, WNT Beta-Catenin upregulators, KY19382, topical estrogen, IGF-1, GH, MK-677, oral castor oil, fisetin, resveratrol, cetrizine, and lactic acid. Users shared experiences and sources for these treatments, with some expressing interest in topical solutions and others noting the lack of FDA approval or scientific evidence for certain options.

community Does RU58841 potentially cause cancer?

in Research/Science 1 year ago

RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.

community My hormone levels after 2 months of Finasteride and 2 weeks of Dutasteride

12 upvotes 2 weeks ago

The conversation discusses elevated hormone levels after using Finasteride for 2 months and Dutasteride for 2 weeks for hair loss. Users suggest that increased testosterone and estradiol levels are expected due to DHT inhibition, and it's not a concern unless symptoms occur.

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Learn

3 / 801 results

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Ethynylestradiol

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