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Glossary Estrogen Receptors

proteins that bind estrogen, influencing cell behavior and function

Estrogen receptors (ER) are proteins found inside and on the surface of certain cells that bind to the hormone estrogen. When estrogen binds to these receptors, it can influence the behavior of the cell, including growth, differentiation, and function. These receptors play a crucial role in various physiological processes, including reproductive health, bone density, and even hair growth. In medical research, ERs are significant in understanding conditions like breast cancer, where the presence of these receptors can influence treatment options.

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Research

5 / 1000+ results

research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that 17-beta-estradiol inhibits hair growth in mice by blocking hair follicles in the telogen phase, whereas an estrogen receptor antagonist promotes hair growth by initiating anagen.

research The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.

research Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling

92 citations , February 2005 in “Endocrinology”

This study found that estrogen receptor beta plays a significant role in murine hair growth control, potentially acting as a silencer of estrogen receptor alpha's catagen-promoting effects.

research Expression patterns of three estrogen receptor genes during zebrafish (Danio rerio) development: evidence for high expression in neuromasts

77 citations , April 2004 in “Gene expression patterns”

This study observed specific expression patterns of three zebrafish estrogen receptor genes during development, highlighting robust co-expression of esr2a and esr2b in primary neuromasts, branchial arches, and other tissues.

research 17β-Estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-α pathway

71 citations , February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

This study found that topical estradiol inhibits hair growth in mice by preventing the hair follicle's transition from resting to growth phase, a process reversible with an estrogen receptor antagonist.

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Community Join

5 / 825 results

community Theaflavin (Black Tea Extract) reduce DHT, androgen receptor activity and estrogen

6 upvotes 3 years ago

Theaflavin, a black tea extract, may inhibit DHT and androgen receptor activity, but its effectiveness for hair loss is debated. Users report no significant improvement with theaflavin, while some find beta sitosterol helpful.

community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 8 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Has anyone powered through the creatine shedding (via increased androgen receptor sensitivity) and stabilized?

9 upvotes 1 year ago

Creatine may cause increased hair shedding due to androgen receptor sensitivity, despite limited evidence. The user is using dutasteride and minoxidil and seeks advice on whether shedding will stabilize, with suggestions including GHK-Cu and RU58841.

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Learn

2 / 800 results

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

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