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      research Deciphering the Complex Immunopathogenesis of Alopecia Areata

      45 citations , May 2024 in “International Journal of Molecular Sciences”
      This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
      GPRC6A-Duox1 Axis Regulates the Hair Cycle Through H2O2 Generation

      research GPRC6A-Duox1 Axis Regulates the Hair Cycle Through H2O2 Generation

      April 2026 in “Tissue Engineering and Regenerative Medicine”
      This study found that the GPRC6A-Duox1 signaling pathway influences hair cycle progression and testosterone-mediated hair loss in mice, suggesting that disruption of this pathway leads to resistance against testosterone-induced hair loss and longer anagen phase duration.
      The Pathogenesis of Alopecia Areata in Rodent Models

      research The Pathogenesis of Alopecia Areata in Rodent Models

      23 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”
      This review discusses rodent models of alopecia areata and suggests they are crucial for understanding the autoimmune mechanisms and potential treatments but reports no new clinical results.

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      community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

       29 upvotes 2 months ago
      Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 2 years ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Green tea/ soy Isoflavones supplements for MPB

       4 upvotes 5 years ago
      Green tea extract and soy isoflavones may help with hair loss by inhibiting DHT and providing additional health benefits. Combining these with finasteride and possibly using nizoral shampoo could enhance effectiveness in managing hair loss.