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GlossaryCytochrome P450

enzymes metabolize drugs and toxins in the liver

Cytochrome P450 (CYP) refers to a large family of enzymes that play a crucial role in the metabolism of various substances within the body, including drugs, toxins, and hormones. These enzymes are primarily found in the liver and are essential for the detoxification process, as well as the synthesis of cholesterol, steroids, and other lipids.

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research Etiopathogenesis and Therapy of Acne: Epidemiological Study of Clinical Characteristics in a Population of Acne Patients and Analysis of Polymorphisms in the Androgen Receptor Gene and Cytochrome P-450 1A1 Gene

January 2008 in “Padua Research Archive (University of Padua)”

Hereditary factors affect acne duration, not severity, and late-onset acne in females has different causes.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research Cytochrome P450: A Target for Drug Development for Skin Diseases

115 citations , August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

research Treatment of Acne Vulgaris: A Literature Review

1 citations , January 2010 in “Serbian Journal of Dermatology and Venereology”

The document concludes that effective acne treatment requires a personalized combination of therapies and long-term commitment, with retinoids being important for maintenance.

research Gene Variants Associated With Acne Vulgaris Presentation and Severity: A Systematic Review and Meta-Analysis

47 citations , April 2021 in “BMC Medical Genomics”

Certain gene variants can influence acne risk and severity.

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community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

in Satire 74 upvotes 2 years ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 2 years ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 1 year ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community How does finasteride leave your body?

in Chat 13 upvotes 1 year ago

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

community How to BECOME a RESPONDER to Fin/Dut if you are not responding

in Finasteride/Dutasteride 303 upvotes 2 years ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

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