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GlossaryCytochrome P450

enzymes metabolize drugs and toxins in the liver

Cytochrome P450 (CYP) refers to a large family of enzymes that play a crucial role in the metabolism of various substances within the body, including drugs, toxins, and hormones. These enzymes are primarily found in the liver and are essential for the detoxification process, as well as the synthesis of cholesterol, steroids, and other lipids.

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research Etiopathogenesis and Therapy of Acne: Epidemiological Study of Clinical Characteristics in a Population of Acne Patients and Analysis of Polymorphisms in the Androgen Receptor Gene and Cytochrome P-450 1A1 Gene

January 2008 in “Padua Research Archive (University of Padua)”

Hereditary factors affect acne duration, not severity, and late-onset acne in females has different causes.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research Pathways to Inflammation: Acne Pathophysiology

68 citations , May 2011 in “European Journal of Dermatology”

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

research Cytochrome P450: A Target for Drug Development for Skin Diseases

115 citations , August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

research Serum Irisin Level in Patients with Acne Vulgaris

January 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences”

Patients with acne vulgaris have lower serum irisin levels.

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community How does finasteride leave your body?

in Chat 13 upvotes 1 year ago

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

in Satire 74 upvotes 2 years ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 22 upvotes 9 months ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 1 year ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

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