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    Glossary Cornified Envelope

    tough, protective layer in the outermost skin part

    The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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    1. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    2. Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes Experimental Dermatology · 2019 · 44 citations
    3. Animal models of human skin disease Experimental Dermatology · 2004 · 4 citations
    4. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    5. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    6. Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2 2022 · 8 citations
    7. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology British Journal of Dermatology · 2012 · 33 citations
    8. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    9. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    10. Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types Journal of Veterinary Science · 2012 · 15 citations
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