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GlossaryAntiandrogenic

substances inhibit male sex hormones like testosterone

Antiandrogenic refers to substances or treatments that inhibit the effects of androgens, which are male sex hormones like testosterone. These substances can be used to treat conditions like androgenic alopecia (hair loss) and prostate cancer by blocking the action of these hormones, thereby reducing their influence on hair follicles and other tissues.

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Tracking 2 products like 259 Pyrilutamide (KX-826) Solution – 30ml 5mg/ml and 262 Pyrilutamide KX-826 Powder – 500mg from by companies like Anageninc. View all 2 products »

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community Choose your topical antiandrogen and tell me why

in Product 7 upvotes 3 months ago

The conversation is about choosing a topical antiandrogen for hair loss, with options including RU58841, CB0301, Pyrolutamide, Alfatradiol, and Fluridil. Users discuss their preferences and reasons for selecting specific treatments.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 5 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community A topical antiandrogen is very necessary to add to the stack, finastride/Dutastride aren't enough to move the needle.

in Update 1 year ago

User added RU and pyrilutamide for hair growth and noticed more baby hairs. Others suggest sticking with fin and min, while some discuss the user's self-image and hair loss severity.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 6 upvotes 1 month ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community Is shedding a good sign for antiandrogens?

in Treatment 1 upvotes 5 days ago

Shedding may indicate potential regrowth when using KX-826, similar to Minoxidil and finasteride. Users report improved hair quality and minor side effects like slight headaches.

community has anyone tried rubbing receipt paper on their heads as a free topical antiandrogen?

in Satire 49 upvotes 1 month ago

This post and conversation are about using receipt paper as a satirical treatment for hair loss. Users humorously discuss various absurd methods, including rubbing, ingesting, and making suppositories out of receipts.

community Obviously, all of us who are serious take antiandrogens and growth stimulants - what else are you doing lifestyle wise, dietary wise, and regiment wise to maximize your results?

in Treatment 21 upvotes 4 months ago

The user follows a hair loss treatment routine including Propecia, oral minoxidil, ketoconazole, and plans to switch to dutasteride. They also focus on lifestyle changes, dietary supplements, and are considering laser therapy.

community For people with overly oily hair, does topical finasteride/dutasteride/antiandrogens (like RU or Pyrilutamide) reduce sebum overproduction?

in Finasteride/Dutasteride 6 upvotes 1 year ago

The conversation discusses whether topical finasteride, dutasteride, or antiandrogens like RU58841 can reduce sebum overproduction as an early indicator of their effectiveness in treating hair loss. It suggests that while hair growth may take months to observe, a decrease in oiliness could be a quicker sign of a product's action.

community Anybody that regrew or thickened up hair with topical dutasteride 0.1% daily or simillar dosage? (without combining finasteride or any other antiandrogens)

in Finasteride/Dutasteride 7 upvotes 2 years ago

The conversation is about someone asking for experiences with hair regrowth using a topical solution containing 0.1% dutasteride, minoxidil, tretinoin, melatonin, and biotin. They want to know if others have had success with a similar treatment without combining it with finasteride or other antiandrogens.

community Severe dry eye: finasteride vs dutasteride

in Finasteride/Dutasteride 9 upvotes 3 years ago

Woman uses antiandrogens for hair thinning prevention, experiences severe dry eye with finasteride. Asks if dutasteride could be better despite potential for worse dry eye.

community Topical androgens for alopecia to treat sebum overproduction on the face

in Product 1 upvotes 8 months ago

The conversation discusses using scalp antiandrogens like RU58841, pyrilutamide, or fluridil on the face to reduce sebum production, noting that clascoterone (winlevi) is an approved facial antiandrogen with underwhelming reviews.

community Binding affinity of pyrilutamide!

in Update 172 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community Why isn't fluridil more widely used and known about?

in Treatment 10 upvotes 3 years ago

Fluridil, an antiandrogen that is not widely used or known about due to its expense and lack of availability in the US. It is suggested as a potential alternative for people who don't want to lower their DHT through treatments such as Minoxidil, Finasteride, Nizoral shampoo, and Dermarolling.

community Does Minoxidil make you lose more hair if you stop it?

in Minoxidil 6 upvotes 3 years ago

The conversation is about someone considering using Minoxidil combined with a weak antiandrogen for hair loss, but is concerned about potential increased hair loss if they stop using Minoxidil. They are seeking others' experiences with stopping Minoxidil and the effects on their hair.

community It’s really unfortunate the CB-03-01 is so expensive.

13 upvotes 6 years ago

The conversation discusses the high cost of CB-03-01, a topical antiandrogen for hair loss, which is considered safe and remains localized upon application. It questions whether the expense is justified compared to the lower risks it poses relative to finasteride.

community Beeezula off label (winlevi compounded)

in Treatment 6 upvotes 3 years ago

User seeks availability of Breezula and its delayed trials. Asks for success with similar topical antiandrogens like fluridil.

community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 6 months ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community I will have it cured by morning

in Research/Science 370 upvotes 1 year ago

Researching the cause of hair loss and treating it by preventing DHT in the scalp with medication such as finasteride or dutasteride, estrogen, minoxidil, dermarolling, and possible topical antiandrogens.

community Density loss after 4 months on DUTASTERIDE, does it get better if you stick with it?

in Finasteride/Dutasteride 3 upvotes 4 months ago

A user experienced increased hair density loss after 4 months on dutasteride combined with finasteride. They are also using topical dutasteride with azelaic acid and alfatradiol but cannot tolerate antiandrogens like RU58841 due to headaches.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 9 months ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community [Research] RU-58841/Pyrilutamide and impacts on male fertility

in Research/Science 6 upvotes 1 year ago

The drugs RU-58841, Pyrilutamide (KX-826), Apalutamide, Enzalutamide, and Darolutamide, which are nonsteroidal antiandrogens (NSAA), potentially impacting male fertility. Pyrilutamide, similar to Enzalutamide, may have reversible effects on fertility.

community My opinions on hair treatment right now and in future

in Treatment 22 upvotes 4 years ago

Finasteride, minoxidil, dermarolling, and topical antiandrogens are effective for hair regrowth. Future treatments may include CB0301 and hair cloning.

community 27yrs Balding since 16 , Progress (Fluridil , Pantostin ,Minoxidil,Stemoxydine,Microneedling,Nizoral)

in Progress Pictures 761 upvotes 7 months ago

A user has been experiencing hair loss since 2013 and has tried various treatments including finasteride, minoxidil, fluridil, pantostin, stemoxydine, microneedling, and Nizoral. They reported improvement after adding antiandrogens and other treatments in July of the previous year but stopped finasteride due to erectile dysfunction.

community If dutesteride and oral minoxidil doesn’t work that’s it right?

in Treatment 41 upvotes 6 months ago

A user is experiencing ongoing hair loss despite using 0.5mg dutasteride and 2.5mg oral minoxidil for several years and is seeking advice. Suggestions include ensuring correct diagnosis, checking for other health issues, considering finasteride, trying topical antiandrogens, and consulting a dermatologist.

community Megadosing Koshine826(Pyrilutamide), my Plan.

in Treatment 1 upvotes 2 months ago

The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

community Anyone on pyrilutamide, and has it increased or decreased your shed?

in Treatment 10 upvotes 3 months ago

The conversation discusses the use of pyrilutamide for hair loss, specifically its impact on shedding. The user is inquiring if others have experienced increased or decreased shedding after starting pyrilutamide.

community Topical spironolactone - anti androgen

in Research/Science 9 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community Topical bicalutamide vs ru58841

in Female 1 upvotes 2 months ago

A user is seeking advice on making a topical bicalutamide solution as an alternative to RU58841 for hair loss, while already using dutasteride and minoxidil. They are considering crushing bicalutamide pills and adding them to their minoxidil.

community What’s your experience with RU58841?

in Treatment 21 upvotes 1 year ago

People shared mixed experiences with RU58841 for hair loss; one person saw no improvement, another had significant gains and uses it with finasteride, while a third had an allergic reaction to the premixed solution. Some mix RU58841 powder into minoxidil themselves.